PMID- 21432822
OWN - NLM
STAT- MEDLINE
DCOM- 20130507
LR  - 20161125
IS  - 1898-018X (Electronic)
IS  - 1898-018X (Linking)
VI  - 18
IP  - 2
DP  - 2011
TI  - Clinical and classic echocardiographic features of patients with, and without, 
      left ventricle reverse remodeling following the introduction of cardiac 
      resynchronization therapy.
PG  - 157-64
AB  - BACKGROUND: The aim of the study was to assess clinical and classic 
      echocardiographic data in patients with different cardiac resynchronization 
      therapy (CRT) outcomes. METHODS: Sixty consecutive patients (aged 66.3 +/- 8.7 
      years, 57 men) with chronic heart failure (CHF) in New York Heart Association 
      (NYHA) classes III-IV despite optimized pharmacotherapy, with left ventricular 
      end-diastolic diameter (LVEDD) > 55 mm, left ventricular ejection fraction  pound 35% 
      and wide QRS complex (>/= 120 ms), including individuals with permanent atrial 
      fibrillation (AF) and single- and dual-chamber pacing, were assessed firstly 
      before, and secondly three months after, biventricular heart stimulator 
      implantation (excluding three patients who died during the follow-up). Patients 
      developing >/= 10% reduction of left ventricular end-systolic volume (LVESV) were 
      classified as responders to CRT. RESULTS: The group of responders (n = 34, 59.7%) 
      and the group of non-responders (n = 23, 40.3%) did not differ regarding baseline 
      echocardiographic parameters or in terms of clinical data of age, gender, 
      concomitant diseases, smoking or pharmacological treatment. The differences 
      involved higher rates of ischemic CHF background, prevalence of hypertension and 
      permanent AF, and a higher concentration of N-terminal pro-B-type natriuretic 
      peptide (NT-proBNP) among the non-responders. In the multivariate logistic 
      regression analysis, NT-proBNP, body mass index (BMI) and the presence of 
      permanent AF correlated negatively with the magnitude of LVESV reduction 
      following CRT introduction. CONCLUSIONS: Classic echocardiographic data did not 
      predict left ventricle reverse remodeling. Higher rates of ischemic CHF 
      aetiology, hypertension, permanent AF and higher NT-proBNP concentration were 
      found in the group without at least 10% LVESV reduction at the three month 
      follow-up. NT-proBNP, BMI and the presence of permanent AF had negative effects 
      on the magnitude of LVESV.
FAU - Wilinski, Jerzy
AU  - Wilinski J
AD  - 1st Department of Cardiology and Hypertension, Jagiellonian University Medical 
      College, Krakow, Poland. putamen@interia.pl
FAU - Czarnecka, Danuta
AU  - Czarnecka D
FAU - Wojciechowska, Wiktoria
AU  - Wojciechowska W
FAU - Kloch-Badelek, Malgorzata
AU  - Kloch-Badelek M
FAU - Jastrzebski, Marek
AU  - Jastrzebski M
FAU - Bacior, Bogumila
AU  - Bacior B
FAU - Sondej, Tomasz
AU  - Sondej T
FAU - Kusak, Piotr
AU  - Kusak P
FAU - Przybyla, Anna
AU  - Przybyla A
FAU - Kawecka-Jaszcz, Kalina
AU  - Kawecka-Jaszcz K
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - Cardiol J
JT  - Cardiology journal
JID - 101392712
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Aged
MH  - Atrial Fibrillation/*diagnostic imaging/epidemiology/*therapy
MH  - Cardiac Resynchronization Therapy/*methods
MH  - Echocardiography/*methods/standards
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Myocardial Ischemia/diagnostic imaging/epidemiology/therapy
MH  - Natriuretic Peptide, Brain/blood
MH  - Peptide Fragments/blood
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - Prognosis
MH  - Ventricular Function, Left
MH  - *Ventricular Remodeling
EDAT- 2011/03/25 06:00
MHDA- 2013/05/08 06:00
CRDT- 2011/03/25 06:00
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2013/05/08 06:00 [medline]
PST - ppublish
SO  - Cardiol J. 2011;18(2):157-64.