PMID- 21435137
OWN - NLM
STAT- MEDLINE
DCOM- 20120321
LR  - 20211020
IS  - 1399-5448 (Electronic)
IS  - 1399-543X (Print)
IS  - 1399-543X (Linking)
VI  - 12
IP  - 8
DP  - 2011 Dec
TI  - Erythrocyte membrane omega-3 fatty acid levels and omega-3 fatty acid intake are 
      not associated with conversion to type 1 diabetes in children with islet 
      autoimmunity: the Diabetes Autoimmunity Study in the Young (DAISY).
PG  - 669-75
LID - 10.1111/j.1399-5448.2011.00760.x [doi]
AB  - AIM: We investigated whether omega-3 fatty acid intake and erythrocyte membrane 
      omega-3 fatty acid levels are associated with conversion to type 1 diabetes in 
      children with islet autoimmunity (IA). METHODS: The Diabetes Autoimmunity Study 
      in the Young is following children at increased genetic risk for type 1 diabetes 
      for the development of persistent IA, as defined as being positive for glutamic 
      acid decarboxylase 65, i, or insulin autoantibodies on two consecutive visits, 
      and then for the development of type 1 diabetes, as diagnosed by a physician. One 
      hundred and sixty-seven children with persistent IA were followed for a mean of 
      4.8 yr, and 45 of these developed type 1 diabetes at a mean age of 8.7 yr. 
      Erythrocyte membrane fatty acids (as a percent of total lipid) and dietary fatty 
      acid intake (estimated via food frequency questionnaire) were analyzed as 
      time-varying covariates in proportional hazards survival analysis, with follow-up 
      time starting at detection of the first autoantibody. RESULTS: Neither dietary 
      intake of omega-3 fatty acids nor omega-6 fatty acids were associated with 
      conversion to type 1 diabetes, adjusting for human leukocyte antigen (HLA)-DR, 
      family history of type 1 diabetes, age at first IA positivity, maternal age, 
      maternal education, and maternal ethnicity. Adjusting for HLA-DR, family history 
      of type 1 diabetes and age at first IA positivity, omega-3 and omega-6 fatty acid 
      levels of erythrocyte membranes were not associated with conversion to type 1 
      diabetes. CONCLUSIONS: In this observational study, omega-3 fatty acid intake and 
      status are not associated with conversion to type 1 diabetes in children with IA.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Miller, Melissa R
AU  - Miller MR
AD  - Department of Epidemiology, Colorado School of Public Health, University of 
      Colorado Anschutz Medical Campus, Campus Box B119, Aurora, CO 80045, USA.
FAU - Yin, Xiang
AU  - Yin X
FAU - Seifert, Jennifer
AU  - Seifert J
FAU - Clare-Salzler, Michael
AU  - Clare-Salzler M
FAU - Eisenbarth, George S
AU  - Eisenbarth GS
FAU - Rewers, Marian
AU  - Rewers M
FAU - Norris, Jill M
AU  - Norris JM
LA  - eng
GR  - P30 DK057516/DK/NIDDK NIH HHS/United States
GR  - P30 DK 57516/DK/NIDDK NIH HHS/United States
GR  - R01 DK049654/DK/NIDDK NIH HHS/United States
GR  - R01 DK032493/DK/NIDDK NIH HHS/United States
GR  - R01-DK32493/DK/NIDDK NIH HHS/United States
GR  - R01-DK49654/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110324
PL  - Denmark
TA  - Pediatr Diabetes
JT  - Pediatric diabetes
JID - 100939345
RN  - 0 (Autoantibodies)
RN  - 0 (Dietary Fats, Unsaturated)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Fatty Acids, Omega-6)
SB  - IM
MH  - Autoantibodies/*blood
MH  - Autoimmunity/genetics
MH  - Child
MH  - Diabetes Mellitus, Type 1/*genetics
MH  - Dietary Fats, Unsaturated/administration & dosage
MH  - Erythrocyte Membrane/*chemistry
MH  - Fatty Acids, Omega-3/administration & dosage/*blood
MH  - Fatty Acids, Omega-6/blood
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Infant
MH  - Islets of Langerhans/*immunology
MH  - Male
PMC - PMC3475955
MID - NIHMS409492
COIS- Conflict of interest The authors declare no conflict of interest.
EDAT- 2011/03/26 06:00
MHDA- 2012/03/22 06:00
PMCR- 2012/10/19
CRDT- 2011/03/26 06:00
PHST- 2011/03/26 06:00 [entrez]
PHST- 2011/03/26 06:00 [pubmed]
PHST- 2012/03/22 06:00 [medline]
PHST- 2012/10/19 00:00 [pmc-release]
AID - 10.1111/j.1399-5448.2011.00760.x [doi]
PST - ppublish
SO  - Pediatr Diabetes. 2011 Dec;12(8):669-75. doi: 10.1111/j.1399-5448.2011.00760.x. 
      Epub 2011 Mar 24.