PMID- 21437187
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2042-003X (Electronic)
IS  - 2090-8091 (Print)
IS  - 2042-003X (Linking)
VI  - 2011
DP  - 2011 Feb 22
TI  - Human Polyomavirus-Associated Cerebral Disorders in the Post-HAART Era.
PG  - 562427
LID - 10.4061/2011/562427 [doi]
LID - 562427
AB  - Human polyomavirus JC is the causative agent of a deadly form of sudden onset 
      dementia, progressive multifocal leukocoencephalopathy (PML). PML is highly 
      prevalent in immunodeficient populations, specially those undergoing 
      chemotherapy, immunosuppressive treatments for autoimmune conditions, and 
      HIV-1/AIDS patients. In fact, before the highly active antiretroviral therapy 
      (HAART) regimens became available, PML was a leading cause of death in HIV-1 
      seropositive individuals. However, patients under HAART show increased survival 
      times with better prognoses. In this report we described the main differences 
      between PML before and after the HAART era; highlighting the new patterns of 
      presentation, the neurotropism of other human polyomaviruses, and the increased 
      prevalence of immune reconstitution inflammatory syndrome (IRIS), as a 
      complication of PML in patients under HAART. Lastly, we propose a revised 
      classification of human poliomavirus-associated cerebral disorders that may 
      reflect more accurately what clinicians encounter in their everyday practice.
FAU - Cedeno-Laurent, Filiberto
AU  - Cedeno-Laurent F
AD  - Harvard Medical School, Boston, MA 02215, USA.
FAU - Penalva de Oliveira, Augusto C
AU  - Penalva de Oliveira AC
FAU - Vidal, Jose E
AU  - Vidal JE
FAU - Trujillo, J Roberto
AU  - Trujillo JR
LA  - eng
PT  - Journal Article
DEP - 20110222
PL  - United States
TA  - Patholog Res Int
JT  - Pathology research international
JID - 101526292
PMC - PMC3062102
EDAT- 2011/03/26 06:00
MHDA- 2011/03/26 06:01
PMCR- 2011/02/22
CRDT- 2011/03/26 06:00
PHST- 2010/12/26 00:00 [received]
PHST- 2011/01/17 00:00 [accepted]
PHST- 2011/03/26 06:00 [entrez]
PHST- 2011/03/26 06:00 [pubmed]
PHST- 2011/03/26 06:01 [medline]
PHST- 2011/02/22 00:00 [pmc-release]
AID - 10.4061/2011/562427 [doi]
PST - epublish
SO  - Patholog Res Int. 2011 Feb 22;2011:562427. doi: 10.4061/2011/562427.