PMID- 21437719
OWN - NLM
STAT- MEDLINE
DCOM- 20120817
LR  - 20221207
IS  - 1433-2965 (Electronic)
IS  - 0937-941X (Linking)
VI  - 23
IP  - 2
DP  - 2012 Feb
TI  - Serum undercarboxylated osteocalcin levels are inversely associated with glycemic 
      status and insulin resistance in an elderly Japanese male population: 
      Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study.
PG  - 761-70
LID - 10.1007/s00198-011-1600-7 [doi]
AB  - SUMMARY: Recent animal studies have demonstrated that undercarboxylated 
      osteocalcin upregulates insulin secretion via osteoblast-insulin signaling. 
      However, it remains unclear whether such a pathway exists in humans. This study 
      showed that serum undercarboxylated osteocalcin levels were inversely associated 
      with fasting plasma glucose, hemoglobin A(1c), and homeostasis model assessment 
      of insulin resistance (HOMA-IR) levels in community-dwelling elderly Japanese 
      men. INTRODUCTION: Undercarboxylated osteocalcin (ucOC) was reported to increase 
      insulin secretion and improve glucose tolerance via osteoblast-insulin signaling 
      in animal-based studies. Whether this pathway also exists in humans is unknown. 
      We aimed to clarify whether serum ucOC levels are associated with glycemic status 
      and insulin resistance in the general Japanese population. METHODS: We included 
      2,174 Japanese men (>/=65 years) who were able to walk without aid from others and 
      lived at home in four cities of Nara Prefecture. We excluded participants with a 
      history of diseases or medications that affect bone metabolism, other than type 2 
      diabetes mellitus (T2DM). Fasting plasma glucose, glycated hemoglobin A(1c), and 
      HOMA-IR levels were determined as outcome measures. RESULTS: Of the 1,597 
      participants included in the analysis, both intact OC (iOC) and ucOC levels 
      showed significant inverse correlations with all outcome measures, even after 
      adjusting for potential confounders. Mean values of outcome measures showed a 
      significant decreasing trend with higher quintiles of iOC or ucOC after adjusting 
      for confounders. This trend remained significant for ucOC quintiles after further 
      adjustment for iOC levels, but was not significant for iOC quintiles after 
      adjusting for ucOC levels. These results were attenuated, but still apparent, 
      after excluding participants receiving drug therapy for T2DM. CONCLUSIONS: Levels 
      of ucOC, but not iOC, were inversely associated with glycemic index and insulin 
      resistance in a population of Japanese men. These findings will need to be 
      confirmed with longitudinal studies.
FAU - Iki, M
AU  - Iki M
AD  - Department of Public Health, Kinki University Faculty of Medicine, 377-2 
      Oono-higashi, Osaka-Sayama, Osaka 589-8511, Japan. masa@med.kindai.ac.jp
FAU - Tamaki, J
AU  - Tamaki J
FAU - Fujita, Y
AU  - Fujita Y
FAU - Kouda, K
AU  - Kouda K
FAU - Yura, A
AU  - Yura A
FAU - Kadowaki, E
AU  - Kadowaki E
FAU - Sato, Y
AU  - Sato Y
FAU - Moon, J S
AU  - Moon JS
FAU - Tomioka, K
AU  - Tomioka K
FAU - Okamoto, N
AU  - Okamoto N
FAU - Kurumatani, N
AU  - Kurumatani N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110325
PL  - England
TA  - Osteoporos Int
JT  - Osteoporosis international : a journal established as result of cooperation 
      between the European Foundation for Osteoporosis and the National Osteoporosis 
      Foundation of the USA
JID - 9100105
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Isoenzymes)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 104982-03-8 (Osteocalcin)
RN  - EC 3.1.3.2 (Acid Phosphatase)
RN  - EC 3.1.3.2 (Tartrate-Resistant Acid Phosphatase)
SB  - IM
CIN - Osteoporos Int. 2013 Oct;24(10):2733. PMID: 23860956
CIN - Osteoporos Int. 2013 Oct;24(10):2735. PMID: 23860957
MH  - Acid Phosphatase/blood
MH  - Aged
MH  - Anthropometry/methods
MH  - Blood Glucose/*metabolism
MH  - Diabetes Mellitus, Type 2/blood/epidemiology
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Insulin Resistance/*physiology
MH  - Isoenzymes/blood
MH  - Japan/epidemiology
MH  - Life Style
MH  - Male
MH  - Osteocalcin/*blood
MH  - Signal Transduction/physiology
MH  - Tartrate-Resistant Acid Phosphatase
EDAT- 2011/03/26 06:00
MHDA- 2012/08/18 06:00
CRDT- 2011/03/26 06:00
PHST- 2010/11/19 00:00 [received]
PHST- 2011/02/08 00:00 [accepted]
PHST- 2011/03/26 06:00 [entrez]
PHST- 2011/03/26 06:00 [pubmed]
PHST- 2012/08/18 06:00 [medline]
AID - 10.1007/s00198-011-1600-7 [doi]
PST - ppublish
SO  - Osteoporos Int. 2012 Feb;23(2):761-70. doi: 10.1007/s00198-011-1600-7. Epub 2011 
      Mar 25.