PMID- 21438666
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20221207
IS  - 1945-0257 (Electronic)
IS  - 1945-0257 (Linking)
VI  - 15
IP  - 7-8
DP  - 2011 Jul-Aug
TI  - Association of PON1 and APOA5 gene polymorphisms in a cohort of Indian patients 
      having coronary artery disease with and without type 2 diabetes.
PG  - 507-12
LID - 10.1089/gtmb.2010.0207 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a major cause of coronary artery disease (CAD) 
      and is responsible for a great deal of morbidity and mortality in Asian Indians. 
      Several gene polymorphisms have been associated with CAD and T2DM in different 
      ethnic groups. This study will give an insight about the association of two 
      selected candidate gene polymorphisms; paraoxonase1 (PON1) Q192R and 
      apolipoprotein A5 (APOA5) -1131T>C were assessed in a cohort of South Indian 
      patients having CAD with and without T2DM. Polymerase chain reaction-based 
      genotyping of PON1 Q192R (rs662) and APOA5-1131T>C (rs662799) polymorphism was 
      carried out in 520 individuals, including 250 CAD patients (160 with T2DM and 90 
      without T2DM), 150 T2DM patients with no identified CAD, and 120 normal healthy 
      sex- and age-matched individuals as controls. The PON1 192RR genotype and R 
      allele frequency were elevated in both CAD and T2DM patients when compared with 
      controls; however, only CAD patients with T2DM showed a statistical significance 
      (p=0.023; OR=1.49; 95% CI: 1.04-2.12) when compared with controls. The 
      APOA5-1131CC genotype and C allele also showed a significant association between 
      the CAD+T2DM patients when compared with CAD without T2DM and healthy controls 
      (p=0.012; OR=1.71; 95% CI: 1.0-2.67). An additive interaction between the PON1 RR 
      and APOA5 TC genotypes was identified between the T2DM and CAD patients (p=0.028 
      and 0.0382, respectively). PON1 and APOA5 polymorphisms may serve as biomarkers 
      in the South Indian population to identify T2DM patients who are at risk of 
      developing CAD.
FAU - Bhaskar, Seema
AU  - Bhaskar S
AD  - Genome Research Group, Centre for Cellular and Molecular Biology, Council for 
      Scientific and Industrial Research, Hyderabad, India. seema@ccmb.res.in
FAU - Ganesan, Mala
AU  - Ganesan M
FAU - Chandak, Giriraj Ratan
AU  - Chandak GR
FAU - Mani, Radha
AU  - Mani R
FAU - Idris, Mohammed M
AU  - Idris MM
FAU - Khaja, Nasaruddin
AU  - Khaja N
FAU - Gulla, Suryaprakash
AU  - Gulla S
FAU - Kumar, Uday
AU  - Kumar U
FAU - Movva, Sireesha
AU  - Movva S
FAU - Vattam, Kiran K
AU  - Vattam KK
FAU - Eppa, Kavita
AU  - Eppa K
FAU - Hasan, Qurratulain
AU  - Hasan Q
FAU - Pulakurthy, Umamaheshwara Reddy
AU  - Pulakurthy UR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110325
PL  - United States
TA  - Genet Test Mol Biomarkers
JT  - Genetic testing and molecular biomarkers
JID - 101494210
RN  - 0 (APOA5 protein, human)
RN  - 0 (Apolipoprotein A-V)
RN  - 0 (Apolipoproteins A)
RN  - EC 3.1.8.1 (Aryldialkylphosphatase)
RN  - EC 3.1.8.1 (PON1 protein, human)
SB  - IM
MH  - Apolipoprotein A-V
MH  - Apolipoproteins A/*genetics
MH  - Aryldialkylphosphatase/*genetics
MH  - Case-Control Studies
MH  - Coronary Artery Disease/epidemiology/etiology/*genetics
MH  - Diabetes Mellitus, Type 2/*complications/epidemiology/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - India/epidemiology
MH  - Male
MH  - Polymerase Chain Reaction/methods
MH  - *Polymorphism, Genetic
MH  - White People/*genetics
EDAT- 2011/03/29 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/03/29 06:00
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 10.1089/gtmb.2010.0207 [doi]
PST - ppublish
SO  - Genet Test Mol Biomarkers. 2011 Jul-Aug;15(7-8):507-12. doi: 
      10.1089/gtmb.2010.0207. Epub 2011 Mar 25.