PMID- 21439243
OWN - NLM
STAT- MEDLINE
DCOM- 20120704
LR  - 20220330
IS  - 1000-467X (Print)
IS  - 1944-446X (Electronic)
IS  - 1944-446X (Linking)
VI  - 30
IP  - 4
DP  - 2011 Apr
TI  - GWAS signals across the HLA regions: revealing a clue for common etiology 
      underlying infectious tumors and other immunity diseases.
PG  - 226-30
AB  - Increasing evidence suggests that multiple genes in the human leukocyte 
      antigen(HLA) regions play an important role in development of cancers and 
      immunity disorders. However, the biological mechanisms of the HLA associations 
      are not well understood. We recently conducted a survey of all genome-wide 
      association studies (GWAS) with significant findings in the HLA regions and 
      concluded that diseases such as cancer and immune disorders are more likely to be 
      associated with genetic variants located in the HLA regions than other diseases. 
      This finding is suggestive for testing a hypothesis of a common etiology of 
      infectious tumors and other immunity diseases.
FAU - Shugart, Yin Yao
AU  - Shugart YY
AD  - Unit of Statistical Genomics, Intramural Research Program, National Institute of 
      Mental Health, National Institute of Health, Bethesda, Maryland 20892, USA. 
      kay1yao@mail.nih.gov
FAU - Wang, Ying
AU  - Wang Y
FAU - Jia, Wei-Hua
AU  - Jia WH
FAU - Zeng, Yi-Xin
AU  - Zeng YX
LA  - eng
GR  - Z99 MH999999/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - England
TA  - Chin J Cancer
JT  - Chinese journal of cancer
JID - 101498232
RN  - 0 (HLA Antigens)
SB  - IM
MH  - *Genetic Predisposition to Disease
MH  - Genetic Variation
MH  - *Genome-Wide Association Study
MH  - HLA Antigens/*genetics/metabolism
MH  - Herpesvirus 4, Human/isolation & purification
MH  - Humans
MH  - Immune System Diseases/*genetics/immunology/virology
MH  - Lymphoma, Non-Hodgkin/genetics/immunology/virology
MH  - Nasopharyngeal Neoplasms/*genetics/immunology/virology
PMC - PMC3381606
MID - NIHMS350073
EDAT- 2011/03/29 06:00
MHDA- 2012/07/05 06:00
PMCR- 2011/04/01
CRDT- 2011/03/29 06:00
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2012/07/05 06:00 [medline]
PHST- 2011/04/01 00:00 [pmc-release]
AID - 1944-446X201104226 [pii]
AID - cjc-30-04-226 [pii]
AID - 10.5732/cjc.011.10075 [doi]
PST - ppublish
SO  - Chin J Cancer. 2011 Apr;30(4):226-30. doi: 10.5732/cjc.011.10075.