PMID- 21439368
OWN - NLM
STAT- MEDLINE
DCOM- 20110913
LR  - 20211020
IS  - 1089-8646 (Electronic)
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 98
IP  - 1
DP  - 2011 Jul
TI  - A search for overlapping genetic susceptibility loci between non-Hodgkin lymphoma 
      and autoimmune diseases.
PG  - 9-14
LID - 10.1016/j.ygeno.2011.03.007 [doi]
AB  - Non-Hodgkin lymphoma (NHL) is a hematological malignancy of the immune system, 
      and, as with autoimmune and inflammatory diseases (ADs), is influenced by genetic 
      variation in the major histocompatibility complex (MHC). Persons with a history 
      of specific ADs also have increased risk of NHL. As the coexistence of ADs and 
      NHL could be caused by factors common to both diseases, here we examined whether 
      some of the associated genetic signals are shared. Overlapping risk loci for NHL 
      subytpes and several ADs were explored using data from genome-wide association 
      studies. Several common genomic regions and susceptibility loci were identified, 
      suggesting a potential shared genetic background. Two independent MHC regions 
      showed the main overlap, with several alleles in the human leukocyte antigen 
      (HLA) class II region exhibiting an opposite risk effect for follicular lymphoma 
      and type I diabetes. These results support continued investigation to further 
      elucidate the relationship between lymphoma and autoimmune diseases.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Conde, Lucia
AU  - Conde L
AD  - Division of Environmental Health Sciences, School of Public Health, University of 
      California, Berkeley, USA. lconde@berkeley.edu
FAU - Bracci, Paige M
AU  - Bracci PM
FAU - Halperin, Eran
AU  - Halperin E
FAU - Skibola, Christine F
AU  - Skibola CF
LA  - eng
GR  - R01 CA122663-01/CA/NCI NIH HHS/United States
GR  - CA89745/CA/NCI NIH HHS/United States
GR  - R01 CA122663-04/CA/NCI NIH HHS/United States
GR  - R01 CA122663-05/CA/NCI NIH HHS/United States
GR  - R01 CA104682-05A2/CA/NCI NIH HHS/United States
GR  - 076113/WT_/Wellcome Trust/United Kingdom
GR  - CA122663/CA/NCI NIH HHS/United States
GR  - R01 CA122663/CA/NCI NIH HHS/United States
GR  - CA104682/CA/NCI NIH HHS/United States
GR  - R01 CA122663-03/CA/NCI NIH HHS/United States
GR  - R01 CA104682/CA/NCI NIH HHS/United States
GR  - R01 CA104682-06/CA/NCI NIH HHS/United States
GR  - R01 CA122663-02/CA/NCI NIH HHS/United States
GR  - 085475/WT_/Wellcome Trust/United Kingdom
GR  - R01 CA104682-07/CA/NCI NIH HHS/United States
GR  - R01 CA045614/CA/NCI NIH HHS/United States
GR  - R03 CA089745/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110323
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Autoimmune Diseases/*genetics/immunology
MH  - Chromosomes, Human, Pair 6
MH  - Female
MH  - Genetic Loci
MH  - *Genetic Predisposition to Disease
MH  - Genome-Wide Association Study
MH  - Haplotypes
MH  - Histocompatibility Antigens Class II/genetics/immunology
MH  - Humans
MH  - Lymphoma, Non-Hodgkin/*genetics/immunology
MH  - Male
MH  - Middle Aged
MH  - Young Adult
PMC - PMC3129413
MID - NIHMS287382
COIS- Conflict of Interest Statement The authors declare no competing financial 
      interest.
EDAT- 2011/03/29 06:00
MHDA- 2011/09/14 06:00
PMCR- 2012/07/01
CRDT- 2011/03/29 06:00
PHST- 2010/10/22 00:00 [received]
PHST- 2011/03/14 00:00 [revised]
PHST- 2011/03/15 00:00 [accepted]
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/09/14 06:00 [medline]
PHST- 2012/07/01 00:00 [pmc-release]
AID - S0888-7543(11)00075-9 [pii]
AID - 10.1016/j.ygeno.2011.03.007 [doi]
PST - ppublish
SO  - Genomics. 2011 Jul;98(1):9-14. doi: 10.1016/j.ygeno.2011.03.007. Epub 2011 Mar 
      23.