PMID- 21439438
OWN - NLM
STAT- MEDLINE
DCOM- 20110719
LR  - 20220330
IS  - 1557-9875 (Electronic)
IS  - 0733-8619 (Linking)
VI  - 29
IP  - 2
DP  - 2011 May
TI  - Multiple sclerosis genetics 2010.
PG  - 219-31
LID - 10.1016/j.ncl.2010.12.002 [doi]
AB  - Multiple sclerosis (MS) is a complex disease involving interactions among 
      multiple genetic loci with modest effects and environment. The human leukocyte 
      antigen (HLA) gene cluster in chromosome 6p21.3 represents by far the strongest 
      MS susceptibility locus genome-wide, with the primary signal arising from the 
      HLA-DRB1gene in the class II segment of the locus. Large, multicenter DNA 
      collections have prospered as the development of new laboratory and analytical 
      approaches has matured at a remarkable pace, allowing the pursuit of 
      comprehensive "agnostic" genome-wide association studies to identify and 
      characterize the non-HLA genetic component of MS. This article summarizes the new 
      knowledge gained from this experimental approach.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - McElroy, Joseph P
AU  - McElroy JP
AD  - Department of Neurology, School of Medicine, University of California at San 
      Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA. 
      Joseph.McElroy@ucsf.edu
FAU - Oksenberg, Jorge R
AU  - Oksenberg JR
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Neurol Clin
JT  - Neurologic clinics
JID - 8219232
RN  - 0 (HLA Antigens)
SB  - IM
MH  - *Genome-Wide Association Study/history
MH  - HLA Antigens/*genetics
MH  - History, 21st Century
MH  - Humans
MH  - Models, Biological
MH  - Multiple Sclerosis/epidemiology/*genetics/history
EDAT- 2011/03/29 06:00
MHDA- 2011/07/20 06:00
CRDT- 2011/03/29 06:00
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/07/20 06:00 [medline]
AID - S0733-8619(10)00155-6 [pii]
AID - 10.1016/j.ncl.2010.12.002 [doi]
PST - ppublish
SO  - Neurol Clin. 2011 May;29(2):219-31. doi: 10.1016/j.ncl.2010.12.002.