PMID- 21439944
OWN - NLM
STAT- MEDLINE
DCOM- 20110719
LR  - 20210503
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 407
IP  - 4
DP  - 2011 Apr 22
TI  - T-817MA, a neuroprotective agent, attenuates the motor and cognitive impairments 
      associated with neuronal degeneration in P301L tau transgenic mice.
PG  - 730-4
LID - 10.1016/j.bbrc.2011.03.091 [doi]
AB  - Tau pathology is implicated in mechanisms of neurodegenerative tauopathies, 
      including Alzheimer's disease (AD) and hereditary frontotemporal dementia and 
      parkinsonism linked to chromosome 17 (FTDP-17). It has been reported that 
      transgenic mice expressing FTDP-17 mutation P301L of human tau (P301L mice) 
      display extensive tau pathology and exhibit behavioral deficits with aging. In 
      this study, we investigated the effects of T-817MA, a neuroprotective agent, on 
      the motor and cognitive impairments associated with neuronal degeneration in 
      P301L mice. T-817MA prevented the progression of motor deficit and the loss of 
      spinal cord motor neurons in P301L mice. Furthermore, T-817MA significantly 
      attenuated the spatial memory impairment and the reduction in synaptic terminal 
      density in the hippocampal dentate gyrus of P301L mice. These results indicate 
      that T-817MA improved the motor and cognitive impairments as a result of 
      inhibiting neuronal degeneration derived from tau pathology in the P301L mice. 
      Therefore, it is expected that T-817MA has a therapeutic potential for 
      tau-related neurodegenerative diseases such as AD.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Fukushima, Tetsuo
AU  - Fukushima T
AD  - Research Laboratories, Toyama Chemical Co., Ltd., Toyama, Japan. 
      tetuo_fukushima@toyama-chemical.co.jp
FAU - Nakamura, Asako
AU  - Nakamura A
FAU - Iwakami, Noboru
AU  - Iwakami N
FAU - Nakada, Yasushi
AU  - Nakada Y
FAU - Hattori, Hiroshi
AU  - Hattori H
FAU - Hoki, Satoru
AU  - Hoki S
FAU - Yamaguchi, Hidetoshi
AU  - Yamaguchi H
FAU - Nakagawa, Masaya
AU  - Nakagawa M
FAU - Terashima, Nobuo
AU  - Terashima N
FAU - Narita, Hirokazu
AU  - Narita H
LA  - eng
PT  - Journal Article
DEP - 20110331
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (1-(3-(2-(1-benzothiophen-5-yl) ethoxy) propyl)-3-azetidinol maleate)
RN  - 0 (Maleates)
RN  - 0 (Mapt protein, mouse)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Synaptophysin)
RN  - 0 (Thiophenes)
RN  - 0 (tau Proteins)
SB  - IM
MH  - Alzheimer Disease/drug therapy/physiopathology
MH  - Animals
MH  - Cognition Disorders/*drug therapy/genetics/physiopathology
MH  - Hippocampus/drug effects/metabolism
MH  - Maleates/*therapeutic use
MH  - Mice
MH  - Mice, Transgenic
MH  - Movement Disorders/*drug therapy/genetics/physiopathology
MH  - Neuroprotective Agents/*therapeutic use
MH  - Synaptophysin/metabolism
MH  - Thiophenes/*therapeutic use
MH  - tau Proteins/genetics
EDAT- 2011/03/29 06:00
MHDA- 2011/07/20 06:00
CRDT- 2011/03/29 06:00
PHST- 2011/03/18 00:00 [received]
PHST- 2011/03/20 00:00 [accepted]
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/07/20 06:00 [medline]
AID - S0006-291X(11)00488-8 [pii]
AID - 10.1016/j.bbrc.2011.03.091 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2011 Apr 22;407(4):730-4. doi: 
      10.1016/j.bbrc.2011.03.091. Epub 2011 Mar 31.