PMID- 21439945
OWN - NLM
STAT- MEDLINE
DCOM- 20110705
LR  - 20220331
IS  - 1873-2968 (Electronic)
IS  - 0006-2952 (Linking)
VI  - 81
IP  - 11
DP  - 2011 Jun 1
TI  - Resveratrol exerts anti-obesity effects via mechanisms involving down-regulation 
      of adipogenic and inflammatory processes in mice.
PG  - 1343-51
LID - 10.1016/j.bcp.2011.03.012 [doi]
AB  - Resveratrol is a natural polyphenolic stilbene derivative found in a variety of 
      edible fruits, including nuts, berries, and grape skin. Although resveratrol has 
      been suggested to improve thermogenesis in the brown adipose tissues of obese 
      animals, there have been no reports on the anti-adipogenic and anti-inflammatory 
      effects of resveratrol in the white adipose tissues of obese animals. The primary 
      aim of this study was to investigate whether resveratrol attenuates high-fat diet 
      (HFD)-induced adipogenesis and inflammation in the epididymal fat tissues of mice 
      and to explore the underlying mechanisms involved in this attenuation. In 
      comparison with HFD-fed mice, mice fed with a 0.4% resveratrol-supplemented diet 
      (RSD) showed significantly lower body weight gain (-48%), visceral fat-pad 
      weights (-58%), and plasma levels of triglyceride, FFA, total cholesterol, 
      glucose, tumor necrosis factor (TNF) alpha, and monocyte chemoattractant protein-1 
      (MCP1). Resveratrol significantly reversed the HFD-induced up-regulation of 
      galanin-mediated signaling molecules (GalR1/2, PKCdelta, Cyc-D, E2F1, and p-ERK) and 
      key adipogenic genes (PPARgamma2, C/EBPalpha, SREBP-1c, FAS, LPL, aP2, and leptin) in the 
      epididymal adipose tissues of mice. Furthermore, resveratrol significantly 
      attenuated the HFD-induced up-regulation of pro-inflammatory cytokines (TNFalpha, 
      IFNalpha, IFNbeta, and IL-6) and their upstream signaling molecules (TLR2/4, MyD88, 
      Tirap, TRIF, TRAF6, IRF5, p-IRF3, and NF-kappaB) in the adipose tissues of mice. The 
      results of this study suggest that resveratrol inhibits visceral adipogenesis by 
      suppressing the galanin-mediated adipogenesis signaling cascade. It may also 
      attenuate cytokine production in the adipose tissue by repressing the TLR2- and 
      TLR4-mediated pro-inflammatory signaling cascades in HFD-fed mice.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Kim, Soyoung
AU  - Kim S
AD  - Department of Food and Nutrition, Yonsei University, Seongsanno Seodaemun-gu, 
      Seoul, South Korea.
FAU - Jin, Yoojeong
AU  - Jin Y
FAU - Choi, Youngshim
AU  - Choi Y
FAU - Park, Taesun
AU  - Park T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110331
PL  - England
TA  - Biochem Pharmacol
JT  - Biochemical pharmacology
JID - 0101032
RN  - 0 (Anti-Obesity Agents)
RN  - 0 (DNA Primers)
RN  - 0 (Stilbenes)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Adipose Tissue/*drug effects
MH  - Animals
MH  - Anti-Obesity Agents/*pharmacology
MH  - Base Sequence
MH  - DNA Primers
MH  - Down-Regulation/*drug effects
MH  - Inflammation/*prevention & control
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Resveratrol
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Stilbenes/*pharmacology
EDAT- 2011/03/29 06:00
MHDA- 2011/07/06 06:00
CRDT- 2011/03/29 06:00
PHST- 2010/12/31 00:00 [received]
PHST- 2011/03/09 00:00 [revised]
PHST- 2011/03/14 00:00 [accepted]
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/07/06 06:00 [medline]
AID - S0006-2952(11)00179-1 [pii]
AID - 10.1016/j.bcp.2011.03.012 [doi]
PST - ppublish
SO  - Biochem Pharmacol. 2011 Jun 1;81(11):1343-51. doi: 10.1016/j.bcp.2011.03.012. 
      Epub 2011 Mar 31.