PMID- 21440129
OWN - NLM
STAT- MEDLINE
DCOM- 20110526
LR  - 20110328
IS  - 1552-6259 (Electronic)
IS  - 0003-4975 (Linking)
VI  - 91
IP  - 4
DP  - 2011 Apr
TI  - Longitudinal follow-up of six-minute walk distance after pulmonary 
      endarterectomy.
PG  - 1094-9
LID - 10.1016/j.athoracsur.2010.11.061 [doi]
AB  - BACKGROUND: The 6-minute walk test is a useful tool to assess functional outcome 
      after pulmonary endarterectomy (PEA) in chronic thromboembolic pulmonary 
      hypertension. However, little is known about the longitudinal dynamics in 
      functional improvement. We performed a longitudinal follow-up of 6-minute walk 
      distance, New York Heart Association functional class, and echocardiography after 
      PEA. METHODS: We studied 71 patients with chronic thromboembolic pulmonary 
      hypertension who underwent PEA. A 6-minute walk test and echocardiography were 
      performed before PEA, at 3 months after, and at annual follow-up. At the time of 
      this report, 52 patients had returned for 2-year follow-up, 32 for 3-year 
      follow-up, 23 for 4-year follow-up, and 11 for 5-year follow-up. RESULTS: 
      Preoperatively, the 6-minute walk distance (6-MWD) correlated with hemodynamic 
      severity of disease (mean pulmonary artery pressure: r = -0.55, p < 0.001); total 
      pulmonary resistance: r = -0.59, p < 0.001) After PEA, 6-MWD increased from 440 +/- 
      109 to 524 +/- 83 meters at 1 year (n = 71, p < 0.001). Further improvement was 
      observed from 523 +/- 87 meters at 1 year to 536 +/- 91 meters at 2 years (n = 52, p 
      < 0.012). After 2 years, no further improvement was observed. At 1 year, the 
      change in 6-MWD from baseline correlated significantly with the change observed 
      in pulmonary hemodynamics. Changes in 6-MWD and hemodynamics were more pronounced 
      in patients with residual pulmonary hypertension after PEA, despite the worse 
      absolute outcome. CONCLUSIONS: In patients with chronic thromboembolic pulmonary 
      hypertension, 6-MWD showed a gradual improvement up to 2 years after PEA. 
      Patients with residual pulmonary hypertension benefited most from treatment, 
      despite the worse absolute outcome.
CI  - Copyright (c) 2011 The Society of Thoracic Surgeons. Published by Elsevier Inc. All 
      rights reserved.
FAU - van der Plas, Mart N
AU  - van der Plas MN
AD  - Department of Respiratory Medicine, Academic Medical Center, University of 
      Amsterdam, Amsterdam, The Netherlands. m.n.vanderplas@amc.uva.nl
FAU - Surie, Sulaiman
AU  - Surie S
FAU - Reesink, Herre J
AU  - Reesink HJ
FAU - van Steenwijk, Reindert P
AU  - van Steenwijk RP
FAU - Kloek, Jaap J
AU  - Kloek JJ
FAU - Bresser, Paul
AU  - Bresser P
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Ann Thorac Surg
JT  - The Annals of thoracic surgery
JID - 15030100R
SB  - IM
CIN - Ann Thorac Surg. 2011 Apr;91(4):1100. PMID: 21440130
MH  - *Endarterectomy
MH  - *Exercise Test/methods
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypertension, Pulmonary/etiology/*surgery
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Embolism/complications/*surgery
MH  - Time Factors
MH  - *Walking
EDAT- 2011/03/29 06:00
MHDA- 2011/05/27 06:00
CRDT- 2011/03/29 06:00
PHST- 2010/05/05 00:00 [received]
PHST- 2010/11/19 00:00 [revised]
PHST- 2010/11/24 00:00 [accepted]
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/05/27 06:00 [medline]
AID - S0003-4975(10)02719-0 [pii]
AID - 10.1016/j.athoracsur.2010.11.061 [doi]
PST - ppublish
SO  - Ann Thorac Surg. 2011 Apr;91(4):1094-9. doi: 10.1016/j.athoracsur.2010.11.061.