PMID- 21440726
OWN - NLM
STAT- MEDLINE
DCOM- 20110722
LR  - 20220321
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 43
IP  - 2
DP  - 2011 Mar
TI  - Genetic polymorphisms of inflammatory molecules in Tunisian kidney 
      transplantation.
PG  - 433-6
LID - 10.1016/j.transproceed.2011.01.029 [doi]
AB  - As chemokines and adhesion molecules play major roles in the process by which 
      leukocytes are recruited from the bloodstream into sites of inflammation, genetic 
      variations in the production or activity of molecules may influence 
      susceptibility to acute rejection episodes. This study sought to determine the 
      impact of recipient monocyte chemoattractant protein-1 (MCP-1), chemokine 
      receptor (CCR2, CCR5), and adhesion molecule (ICAM-1, PECAM-1 and L/E selectin) 
      polymorphisms on acute rejection after renal transplantation. We selected 169 
      healthy blood donors and 173 renal transplant recipients for analysis according 
      to the presence or absence of graft rejection in the first 30 days after 
      transplantation. Using molecular methods DNA was genotyped for 11 polymorphisms 
      of these inflammatory molecules genes. Results were stratified by the incidence 
      of rejection episodes and by human leukocyte antigen (HLA) mismatching. No 
      association was detected between adhesion molecule polymorphisms and the 
      incidence of acute rejection episodes. However, a significant risk of acute renal 
      loss was observed among HLA-identical recipients who possessed the CCR2-64I 
      allele (odds ratio 0.24, 95% confidence interval, 0.05 to 1.06; P=.035). In 
      conclusion, the observed association of CCR2-64I with acute rejection episodes 
      should be added to the spectrum of immunogenetic factors known to be involved in 
      renal allograft rejection.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Krichen, H
AU  - Krichen H
AD  - Research Laboratory of Transplantation Immunopathology (LR01SP03), University 
      Tunis El Manar, Department of Nephrology, Charles Nicolle Hospital, Tunis, 
      Tunisia.
FAU - Khazen, D
AU  - Khazen D
FAU - Sfar, I
AU  - Sfar I
FAU - Ben Abdallah, T
AU  - Ben Abdallah T
FAU - Bardi, R
AU  - Bardi R
FAU - Jendoubi-Ayed, S
AU  - Jendoubi-Ayed S
FAU - Makhlouf, M
AU  - Makhlouf M
FAU - Abderrahim, E
AU  - Abderrahim E
FAU - Aouadi, H
AU  - Aouadi H
FAU - Ayed, K
AU  - Ayed K
FAU - Gorgi, Y
AU  - Gorgi Y
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (Chemokines)
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, CCR2)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Blood Donors
MH  - Chemokines/*metabolism
MH  - Female
MH  - Graft Rejection
MH  - HLA Antigens/metabolism
MH  - Humans
MH  - Inflammation
MH  - Kidney Failure, Chronic/genetics/therapy
MH  - Kidney Transplantation/*methods
MH  - Male
MH  - *Polymorphism, Genetic
MH  - Receptors, CCR2/*genetics
MH  - Tunisia
EDAT- 2011/03/29 06:00
MHDA- 2011/07/23 06:00
CRDT- 2011/03/29 06:00
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/07/23 06:00 [medline]
AID - S0041-1345(11)00030-3 [pii]
AID - 10.1016/j.transproceed.2011.01.029 [doi]
PST - ppublish
SO  - Transplant Proc. 2011 Mar;43(2):433-6. doi: 10.1016/j.transproceed.2011.01.029.