PMID- 21440744
OWN - NLM
STAT- MEDLINE
DCOM- 20110722
LR  - 20131121
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 43
IP  - 2
DP  - 2011 Mar
TI  - Influence of 1,25-dihydroxyvitamin D3 on human leukocyte antigen-DR expression, 
      macrophage infiltration, and graft survival in renal allografts.
PG  - 500-3
LID - 10.1016/j.transproceed.2011.01.083 [doi]
AB  - Vitamin D plays an important role in the regulation of cellular growth and cell 
      proliferation as well as exerting immunoregulatory activities. We sought to show 
      the influence of vitamin D on renal graft survival. Among 102 patients, 40 were 
      treated with vitamin D (group D) and the remaining 62 cases were not, forming a 
      control group (group C). We studied human leukocyte antigen (HLA)-DR expression 
      on tubules, interstitial cells, peritubular capillaries (PTCs), and evaluated 
      macrophage infiltration of the interstitium and the PTCs. Compared to group C, 
      group D patients showed fewer acute rejection episodes. Compared to group C 
      patients group D patients showed significantly lower degrees of tubular and 
      interstitial HLA-DR expression as well as interstitial and PTC macrophage 
      infiltration. In addition in the PTC, HLA-DR expression was greater and therefore 
      PTC destruction less in group D patients (P<.001). Twenty-seven (43.5%) of 62 
      group C patients lost their grafts at 29.2+/-15 months, whereas only 7/40 (17.5%) 
      group D patients lost their grafts at 43.2+/-13 months. A significant difference 
      was noted between the two groups in regard to the time of graft loss (P<.01). 
      Testing vitamin D therapy along with several other covariates showed an 
      independent effect on 5-year graft survival (P<.001). These data confirmed that 
      vitamin D therapy shows an independent positive impact on long-term graft 
      survival, which may be explained by its immunosuppressive effects of to reduce 
      renal HLA-DR expression and renal macrophage infiltration and in turn mitigate 
      PTC destruction. In conclusion, these results highlighted the potential use of 
      vitamin D in renal allograft patients.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Ozdemir, B H
AU  - Ozdemir BH
AD  - Department of Pathology, Baskent University, Ankara, Turkey. handan27@hotmail.com
FAU - Ozdemir, A A
AU  - Ozdemir AA
FAU - Sezer, S
AU  - Sezer S
FAU - Colak, T
AU  - Colak T
FAU - Haberal, M
AU  - Haberal M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (HLA-DR Antigens)
RN  - FXC9231JVH (Calcitriol)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biopsy
MH  - Calcitriol/*pharmacology
MH  - Capillaries/metabolism
MH  - Female
MH  - *Gene Expression Regulation
MH  - Graft Rejection
MH  - Graft Survival
MH  - HLA-DR Antigens/*biosynthesis
MH  - Humans
MH  - Kidney Transplantation/*methods
MH  - Kidney Tubules/metabolism
MH  - Macrophages/cytology/metabolism
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2011/03/29 06:00
MHDA- 2011/07/23 06:00
CRDT- 2011/03/29 06:00
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/07/23 06:00 [medline]
AID - S0041-1345(11)00167-9 [pii]
AID - 10.1016/j.transproceed.2011.01.083 [doi]
PST - ppublish
SO  - Transplant Proc. 2011 Mar;43(2):500-3. doi: 10.1016/j.transproceed.2011.01.083.