PMID- 21440871
OWN - NLM
STAT- MEDLINE
DCOM- 20110713
LR  - 20231104
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Print)
IS  - 1071-9164 (Linking)
VI  - 17
IP  - 4
DP  - 2011 Apr
TI  - Three gram sodium intake is associated with longer event-free survival only in 
      patients with advanced heart failure.
PG  - 325-30
LID - 10.1016/j.cardfail.2010.11.008 [doi]
AB  - BACKGROUND: There is limited evidence to support the recommendation that patients 
      with heart failure (HF) restrict sodium intake. The purpose of this study was to 
      compare differences in cardiac event-free survival between patients with sodium 
      intake above and below 3 g. METHODS: A total of 302 patients with HF (67% male, 
      62 +/- 12 years, 54% New York Heart Association [NYHA] Class III/IV, ejection 
      fraction 34 +/- 14%) collected a 24-hour urine sodium (UNa) to indicate sodium 
      intake. Patients were divided into 2 groups using a 3-g UNa cutpoint and 
      stratified by NYHA Class (I/II vs. III/IV). Event-free survival for 12 months was 
      determined by patient or family interviews and medical record review. Differences 
      in cardiac event-free survival were determined by Kaplan-Meier survival curve 
      with log-rank test and Cox hazard regression. RESULTS: The Cox regression hazard 
      ratio for 24-hour UNa >/= 3 g in NYHA Class I/II was 0.44 (95% confidence interval 
      [CI] = 0.20-0.97) and 2.54 (95% CI = 1.10-5.84) for NYHA III/IV after controlling 
      for age, gender, HF etiology, body mass index, ejection fraction, and total 
      comorbidity score. CONCLUSIONS: These data suggest that 3 g dietary sodium 
      restriction may be most appropriate for patients in NYHA functional Classes III 
      and IV.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Lennie, Terry A
AU  - Lennie TA
AD  - University of Kentucky, College of Nursing, 751 Rose Street, Lexington, KY 40536, 
      USA. tlennie@uky.edu
FAU - Song, Eun Kyeung
AU  - Song EK
FAU - Wu, Jia-Rong
AU  - Wu JR
FAU - Chung, Misook L
AU  - Chung ML
FAU - Dunbar, Sandra B
AU  - Dunbar SB
FAU - Pressler, Susan J
AU  - Pressler SJ
FAU - Moser, Debra K
AU  - Moser DK
LA  - eng
GR  - M01 RR000039-39/RR/NCRR NIH HHS/United States
GR  - M01RR02602/RR/NCRR NIH HHS/United States
GR  - R01 NR009280/NR/NINR NIH HHS/United States
GR  - R01 NR009280-03/NR/NINR NIH HHS/United States
GR  - M01 RR000750-27/RR/NCRR NIH HHS/United States
GR  - M01RR0039/RR/NCRR NIH HHS/United States
GR  - M01 RR000039/RR/NCRR NIH HHS/United States
GR  - M01 RR000750/RR/NCRR NIH HHS/United States
GR  - UL1 TR000454/TR/NCATS NIH HHS/United States
GR  - M01 RR002602-17/RR/NCRR NIH HHS/United States
GR  - P20 NR010679-03/NR/NINR NIH HHS/United States
GR  - P20 NR010679/NR/NINR NIH HHS/United States
GR  - R01 NR 009280/NR/NINR NIH HHS/United States
GR  - 1P20NR010679/NR/NINR NIH HHS/United States
GR  - M01 RR002602/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110121
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
RN  - 0 (Sodium, Dietary)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Diet, Sodium-Restricted
MH  - Disease-Free Survival
MH  - Female
MH  - Heart Failure/*diet therapy
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Sodium, Dietary/*administration & dosage
MH  - Survival Analysis
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC3073718
MID - NIHMS259045
EDAT- 2011/03/29 06:00
MHDA- 2011/07/14 06:00
PMCR- 2012/04/01
CRDT- 2011/03/29 06:00
PHST- 2010/08/13 00:00 [received]
PHST- 2010/11/18 00:00 [revised]
PHST- 2010/11/22 00:00 [accepted]
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/07/14 06:00 [medline]
PHST- 2012/04/01 00:00 [pmc-release]
AID - S1071-9164(10)01228-5 [pii]
AID - 10.1016/j.cardfail.2010.11.008 [doi]
PST - ppublish
SO  - J Card Fail. 2011 Apr;17(4):325-30. doi: 10.1016/j.cardfail.2010.11.008. Epub 
      2011 Jan 21.