PMID- 21441703
OWN - NLM
STAT- MEDLINE
DCOM- 20110902
LR  - 20190907
IS  - 1348-4540 (Electronic)
IS  - 0918-8959 (Linking)
VI  - 58
IP  - 4
DP  - 2011
TI  - Attenuated expression of menin and p27 (Kip1) in an aggressive case of multiple 
      endocrine neoplasia type 1 (MEN1) associated with an atypical prolactinoma and a 
      malignant pancreatic endocrine tumor.
PG  - 287-96
AB  - Tumors in multiple endocrine neoplasia type 1 (MEN1) are generally benign. Since 
      information on the pathogenesis of MEN1 in malignant cases is limited, we 
      conducted genetic analysis and compared the expression of menin, 
      p27(Kip1)(p27)/CDKN1B and p18(Ink4C)(p18)/CDKN2C with levels in benign cases. We 
      describe the case of a 56 year-old male with an atypical prolactinoma and 
      malignant pancreatic neuroenocrine tumor. At age 50, he had undergone 
      transsphenoidal surgery to remove a prolactinoma. However, the tumor relapsed 
      twice. Histological analysis of the recurrent prolactinoma revealed the presence 
      of prolactin, a high MIB-1 index (32.1 %), p53-positive cells (0.2%), and an 
      unusual association with FSH-positive cells. A few years later, he was also found 
      to have a non-functioning pancreatic tumor with probable metastasis to the 
      extradullar region. The metastatic region tested positive for chromogranin and 
      CD56, and negative for prolactin, with 1.2 % of cells p53-positive. Although 
      genetic analyses of the MEN1, p27, and p18 genes demonstrated no mutation, 
      numbers of menin, p27 and p18 immuno-positive cells were significantly 
      down-regulated in the recurrent prolactinoma, but that of p18 was intact in the 
      metastatic region. Furthermore, MEN1 and p27 mRNA levels of the recurrent 
      prolactinoma were down-regulated, particularly the MEN1 mRNA level, compared to 
      levels in 10 cases of benign prolactinoma, while the p18 mRNA level was similar 
      to that of normal pituitary. The tumor in this case may be a subtype of MEN1 
      showing more aggressive and malignant features probably induced by low levels of 
      menin and p27.
FAU - Ishida, Emi
AU  - Ishida E
AD  - Department of Medicine and Molecular Science, Gunma University Graduate School of 
      Medicine, Maebashi, Japan.
FAU - Yamada, Masanobu
AU  - Yamada M
FAU - Horiguchi, Kazuhiko
AU  - Horiguchi K
FAU - Taguchi, Ryo
AU  - Taguchi R
FAU - Ozawa, Atsushi
AU  - Ozawa A
FAU - Shibusawa, Nobuyuki
AU  - Shibusawa N
FAU - Hashimoto, Koshi
AU  - Hashimoto K
FAU - Satoh, Tetsuro
AU  - Satoh T
FAU - Yoshida, Sachiko
AU  - Yoshida S
FAU - Tanaka, Yoshiki
AU  - Tanaka Y
FAU - Yokota, Machiko
AU  - Yokota M
FAU - Tosaka, Masahiko
AU  - Tosaka M
FAU - Hirato, Junko
AU  - Hirato J
FAU - Yamada, Shozo
AU  - Yamada S
FAU - Yoshimoto, Yuhei
AU  - Yoshimoto Y
FAU - Mori, Masatomo
AU  - Mori M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110325
PL  - Japan
TA  - Endocr J
JT  - Endocrine journal
JID - 9313485
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p18)
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 147604-94-2 (Cyclin-Dependent Kinase Inhibitor p27)
SB  - IM
MH  - Cyclin-Dependent Kinase Inhibitor p18/genetics
MH  - Cyclin-Dependent Kinase Inhibitor p27/*biosynthesis/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*metabolism/pathology
MH  - Neoplasm Recurrence, Local
MH  - Pancreatic Neoplasms/genetics/*metabolism/pathology
MH  - Pituitary Neoplasms/secondary
MH  - Prolactinoma/*metabolism/surgery
MH  - Proto-Oncogene Proteins/*biosynthesis
EDAT- 2011/03/29 06:00
MHDA- 2011/09/03 06:00
CRDT- 2011/03/29 06:00
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/09/03 06:00 [medline]
AID - JST.JSTAGE/endocrj/K10E-158 [pii]
AID - 10.1507/endocrj.k10e-158 [doi]
PST - ppublish
SO  - Endocr J. 2011;58(4):287-96. doi: 10.1507/endocrj.k10e-158. Epub 2011 Mar 25.