PMID- 21442262 OWN - NLM STAT- MEDLINE DCOM- 20120906 LR - 20211020 IS - 1875-8312 (Electronic) IS - 1569-5794 (Linking) VI - 28 IP - 3 DP - 2012 Mar TI - Magnetic resonance assessment of left ventricular diastolic dysfunction for detecting cardiac allograft vasculopathy in recipients of heart transplants. PG - 555-62 LID - 10.1007/s10554-011-9853-y [doi] AB - Cardiac allograft vasculopathy (CAV) is a major late complication in heart transplant recipients, graded based on intravascular ultrasound (IVUS), and accelerates left ventricular (LV) diastolic dysfunction. We investigated the clinical feasibility of using magnetic resonance (MR) to assess LV diastolic dysfunction noninvasively in transplant recipients. Thirty-eight asymptomatic recipients (25 men, 37.2 +/- 14.9 years) underwent both IVUS and cardiac MR. Based on IVUS, we divided the individuals into 2 groups using Stanford classification to categorize CAV development as either nonsignificant or advanced. We measured LV peak filling rate (PFR) and systolic function parameters, including LV ejection fraction (EF), stroke volume (SV), and cardiac output (CO) using cine MR; compared those values between groups; calculated receiver operating characteristic curve in the relationship between PFR value and CAV; and assessed myocardial late gadolinium enhancement (LGE) on contrast-enhanced MR. We classified CAV as advanced in 20 patients (53%) and nonsignificant in 18 (47%). LV EF, SV, and CO values were not significantly different. PFR was significantly lower in the advanced (3.63 +/- 0.90 EDV/s) than nonsignificant group (4.43 +/- 0.84 EDV/s, P = 0.01). The area under the curve was 0.76. We observed no myocardial LGE. MR measurement of PFR may permit noninvasive assessment of diastolic dysfunction associated with CAV before LV systolic dysfunction and myocardial infarction or scar formation develop. FAU - Machida, Haruhiko AU - Machida H AD - Department of Radiology, Medical Center East, Tokyo Women's Medical University, 2-1-10 Nishiogu, Arakawa-ku, Tokyo 116-8567, Japan. machira@dnh.twmu.ac.jp FAU - Nunoda, Shinichi AU - Nunoda S FAU - Okajima, Kiyotaka AU - Okajima K FAU - Shitakura, Kazunobu AU - Shitakura K FAU - Sekikawa, Akihiko AU - Sekikawa A FAU - Kubo, Yutaka AU - Kubo Y FAU - Otsuka, Kuniaki AU - Otsuka K FAU - Hirata, Masami AU - Hirata M FAU - Kojima, Shinya AU - Kojima S FAU - Ueno, Eiko AU - Ueno E LA - eng PT - Comparative Study PT - Journal Article DEP - 20110326 PL - United States TA - Int J Cardiovasc Imaging JT - The international journal of cardiovascular imaging JID - 100969716 RN - 0 (Contrast Media) SB - IM MH - Adult MH - Age Factors MH - Contrast Media MH - Coronary Artery Disease/*diagnosis/etiology/physiopathology MH - Early Diagnosis MH - Feasibility Studies MH - Female MH - Heart Transplantation/*adverse effects MH - Humans MH - Japan MH - Linear Models MH - *Magnetic Resonance Imaging, Cine MH - Male MH - Middle Aged MH - Myocardial Infarction/diagnosis/etiology/physiopathology MH - Predictive Value of Tests MH - ROC Curve MH - Retrospective Studies MH - Severity of Illness Index MH - *Stroke Volume MH - Treatment Outcome MH - Ultrasonography, Interventional MH - Ventricular Dysfunction, Left/*diagnosis/etiology/physiopathology MH - *Ventricular Function, Left MH - Young Adult EDAT- 2011/03/29 06:00 MHDA- 2012/09/07 06:00 CRDT- 2011/03/29 06:00 PHST- 2010/08/22 00:00 [received] PHST- 2011/03/16 00:00 [accepted] PHST- 2011/03/29 06:00 [entrez] PHST- 2011/03/29 06:00 [pubmed] PHST- 2012/09/07 06:00 [medline] AID - 10.1007/s10554-011-9853-y [doi] PST - ppublish SO - Int J Cardiovasc Imaging. 2012 Mar;28(3):555-62. doi: 10.1007/s10554-011-9853-y. Epub 2011 Mar 26.