PMID- 21442436
OWN - NLM
STAT- MEDLINE
DCOM- 20120207
LR  - 20161125
IS  - 1439-7609 (Electronic)
IS  - 1439-7595 (Linking)
VI  - 21
IP  - 5
DP  - 2011 Oct
TI  - Phonoarthrography, musculoskeletal ultrasonography, and biochemical biomarkers 
      for the evaluation of knee cartilage in osteoarthritis.
PG  - 500-8
LID - 10.1007/s10165-011-0441-8 [doi]
AB  - The aim of this study was to examine the relationship among three different 
      parameters used to assess cartilage in osteoarthritis (OA) of the knee. These 
      parameters are phonoarthrography (Phono-A), musculoskeletal ultrasonography 
      (MSUS) from the 4 condyles, and biochemical markers; notably, matrix 
      metalloproteinase-3 (MMP-3) and tissue inhibitor of proteinase (TIMP-1). A total 
      of 100 knees with chronic idiopathic OA diagnosed according to the American 
      College of Rheumatology (ACR) criteria were studied, together with 50 normal 
      knees. The knee sounds were recorded by Phono-A and the cartilage thickness was 
      measured by MSUS. All patients and controls had MMP-3 and TIMP-1 measured in a 
      blood sample, using an enzyme-linked immunosorbent assay (ELISA). Conventional 
      knee X-rays were obtained for diagnosis and for Kellgren-Lawrence (K-L) grading 
      purposes. The results showed that Phono-A values were inversely correlated with 
      cartilage thickness, both of these being sensitive parameters for cartilage 
      degeneration. Phono-A values were higher in patients than in controls, denoting 
      more degeneration of cartilage, and the cartilage thickness of all 4 condyles 
      showed significant reductions in patients compared with normal controls. Most of 
      the patients were categorized as grade 2 (36%) and grade 3 (30%) of the K-L 
      classification. Mean levels of MMP-3 and TIMP-1 were significantly elevated in 
      both groups but they were not correlated with each other. MMP-3 continued to rise 
      with increasing radiological grades until grade 4, where it fell unexpectedly. In 
      conclusion, Phono-A and cartilage thickness measured by MSUS seem to support each 
      other. They can be used as parameters for following up cartilage in OA of the 
      knees. The first deals with the roughness of the cartilage surface and the second 
      with its thickness, complementing each other. MMP-3 continues to rise in early 
      and middle grades of OA, denoting cartilage destruction.
FAU - Bassiouni, Hassan M
AU  - Bassiouni HM
AD  - Department of Rheumatology, Al-Azhar University 4, Shohada St, Mohandesin, Cairo, 
      Egypt. hassanbassiouni@yahoo.com
FAU - El-Deeb, Mamoun
AU  - El-Deeb M
FAU - Kenawy, Nasser
AU  - Kenawy N
FAU - Abdul-Azim, Ehab
AU  - Abdul-Azim E
FAU - Khairy, Mamdouh
AU  - Khairy M
LA  - eng
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
DEP - 20110327
PL  - England
TA  - Mod Rheumatol
JT  - Modern rheumatology
JID - 100959226
RN  - 0 (Biomarkers)
RN  - 0 (TIMP1 protein, human)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arthrography/methods
MH  - Biomarkers/blood
MH  - Cartilage, Articular/*diagnostic imaging/*metabolism
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Knee Joint/diagnostic imaging/metabolism
MH  - Male
MH  - Matrix Metalloproteinase 3/blood
MH  - Middle Aged
MH  - Osteoarthritis, Knee/*diagnostic imaging/*metabolism
MH  - Severity of Illness Index
MH  - Tissue Inhibitor of Metalloproteinase-1/blood
MH  - Ultrasonics/methods
MH  - Ultrasonography/*methods
MH  - Young Adult
EDAT- 2011/03/29 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/03/29 06:00
PHST- 2010/11/22 00:00 [received]
PHST- 2011/02/21 00:00 [accepted]
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - 10.1007/s10165-011-0441-8 [doi]
PST - ppublish
SO  - Mod Rheumatol. 2011 Oct;21(5):500-8. doi: 10.1007/s10165-011-0441-8. Epub 2011 
      Mar 27.