PMID- 21443136
OWN - NLM
STAT- MEDLINE
DCOM- 20110421
LR  - 20131121
IS  - 0172-6390 (Print)
IS  - 0172-6390 (Linking)
VI  - 57
IP  - 104
DP  - 2010 Nov-Dec
TI  - Does pretreatment with proton pump inhibitors influence the eradication rate of 
      Helicobacter pylori?
PG  - 1645-9
AB  - BACKGROUND/AIMS: Pretreatment with a proton pump inhibitor (PPI) has been 
      reported to decrease the efficacy of Helicobacter pylori (H. pylori) eradication. 
      We compared the efficacy of an eradication regimen 
      (lansoprazole/amoxicillin/clarithromycin) first or following pretreatment with a 
      PPI. METHODOLOGY: In this retrospective study conducted at three centers, 353 
      patients infected with H. pylori were treated. The H. pylori status was 
      determined using the rapid urease test, bacterial cultures, and the histological 
      examination of endoscopic biopsy specimens, The patients were assigned to receive 
      an eradication regimen first or following pretreatment with a PPI. Eradication 
      was assessed using the 13C-urea breath test more than 4 weeks after the 
      completion of therapy. RESULTS: Overall, H. pylori was eradicated in 78.8% of the 
      cases: 79.6% in the pretreatment group, and 77.6% in the eradication first group 
      (p = 0.6541 by chi square test). No significant difference in the eradication 
      rates was observed between the two groups. CONCLUSIONS: This retrospective study 
      indicated that pretreatment with a PPI does not significantly reduce the efficacy 
      of eradication therapy in patients infected with H. pylori.
FAU - Tokoro, Chikako
AU  - Tokoro C
AD  - Gastroenterology Division, Yokohama City University Hospital, 3-9 Fukuura, 
      Kanazawa-ku, Yokohama, 236-0004, Japan.
FAU - Inamori, Masahiko
AU  - Inamori M
FAU - Koide, Tomoko
AU  - Koide T
FAU - Iida, Hiroshi
AU  - Iida H
FAU - Sakamoto, Yasunari
AU  - Sakamoto Y
FAU - Endo, Hiroki
AU  - Endo H
FAU - Hosono, Kunihiro
AU  - Hosono K
FAU - Takahashi, Hirokazu
AU  - Takahashi H
FAU - Yoneda, Masato
AU  - Yoneda M
FAU - Yasuzaki, Hiroaki
AU  - Yasuzaki H
FAU - Ogawa, Masami
AU  - Ogawa M
FAU - Abe, Yasunobu
AU  - Abe Y
FAU - Kubota, Kensuke
AU  - Kubota K
FAU - Saitou, Satoru
AU  - Saitou S
FAU - Kawana, Ichiro
AU  - Kawana I
FAU - Matsuda, Reikei
AU  - Matsuda R
FAU - Takahashi, Daisuke
AU  - Takahashi D
FAU - Nakajima, Atsushi
AU  - Nakajima A
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Hepatogastroenterology
JT  - Hepato-gastroenterology
JID - 8007849
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Proton Pump Inhibitors)
RN  - 0K5C5T2QPG (Lansoprazole)
RN  - 804826J2HU (Amoxicillin)
RN  - H1250JIK0A (Clarithromycin)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles/administration & dosage
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Amoxicillin/administration & dosage
MH  - Chi-Square Distribution
MH  - Clarithromycin/administration & dosage
MH  - Drug Therapy, Combination
MH  - Female
MH  - Helicobacter Infections/*drug therapy
MH  - *Helicobacter pylori
MH  - Humans
MH  - Lansoprazole
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Premedication
MH  - Proton Pump Inhibitors/*administration & dosage
MH  - Retrospective Studies
MH  - Statistics, Nonparametric
EDAT- 2011/03/30 06:00
MHDA- 2011/04/22 06:00
CRDT- 2011/03/30 06:00
PHST- 2011/03/30 06:00 [entrez]
PHST- 2011/03/30 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
PST - ppublish
SO  - Hepatogastroenterology. 2010 Nov-Dec;57(104):1645-9.