PMID- 21445551
OWN - NLM
STAT- MEDLINE
DCOM- 20110816
LR  - 20211020
IS  - 1548-3576 (Electronic)
IS  - 1548-3568 (Linking)
VI  - 8
IP  - 2
DP  - 2011 Jun
TI  - Antiretroviral therapy: a key component of a comprehensive HIV prevention 
      strategy.
PG  - 85-93
LID - 10.1007/s11904-011-0076-6 [doi]
AB  - Transmission of HIV is critically dependent on the level of HIV viral load within 
      blood and genital secretions. Antiretroviral therapy results in sustained 
      reductions in viral load to undetectable levels. Thus, antiretroviral therapy has 
      long been postulated as a potential means to curb HIV transmission. Observational 
      data have now confirmed that antiretroviral therapy is associated with a decrease 
      in transmission among heterosexual serodiscordant couples, injection-drug users, 
      and in population-based studies. Mathematical models suggest that further 
      expansion of antiretroviral coverage within current guidelines can play a major 
      role in controlling the spread of HIV. Concerns regarding the potential for 
      transmission during acute HIV infection, behavioral disinhibition, and resistance 
      to overcome the impact of treatment on prevention have not materialized to date. 
      The Joint United Nations AIDS (UNAIDS) program has called for the inclusion of 
      antiretroviral treatment as a key pillar in the global strategy to control the 
      spread of HIV infection.
FAU - Hull, Mark W
AU  - Hull MW
AD  - British Columbia-Centre for Excellence in HIV/AIDS, at St Paul's Hospital, 
      Providence Health Care and Division of AIDS, Department of Medicine, University 
      of British Columbia, Vancouver, Canada.
FAU - Montaner, Julio
AU  - Montaner J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr HIV/AIDS Rep
JT  - Current HIV/AIDS reports
JID - 101235661
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Anti-HIV Agents/*therapeutic use
MH  - Antiretroviral Therapy, Highly Active
MH  - HIV Infections/epidemiology/*prevention & control/transmission
MH  - Humans
MH  - Infectious Disease Transmission, Vertical/prevention & control
MH  - Viral Load
EDAT- 2011/03/30 06:00
MHDA- 2011/08/17 06:00
CRDT- 2011/03/30 06:00
PHST- 2011/03/30 06:00 [entrez]
PHST- 2011/03/30 06:00 [pubmed]
PHST- 2011/08/17 06:00 [medline]
AID - 10.1007/s11904-011-0076-6 [doi]
PST - ppublish
SO  - Curr HIV/AIDS Rep. 2011 Jun;8(2):85-93. doi: 10.1007/s11904-011-0076-6.