PMID- 21445726 OWN - NLM STAT- MEDLINE DCOM- 20110808 LR - 20211020 IS - 1435-165X (Electronic) IS - 1018-8827 (Linking) VI - 20 IP - 4 DP - 2011 Apr TI - European clinical guidelines for Tourette syndrome and other tic disorders. Part IV: deep brain stimulation. PG - 209-17 LID - 10.1007/s00787-011-0166-4 [doi] AB - Ten years ago deep brain stimulation (DBS) has been introduced as an alternative and promising treatment option for patients suffering from severe Tourette syndrome (TS). It seemed timely to develop a European guideline on DBS by a working group of the European Society for the Study of Tourette Syndrome (ESSTS). For a narrative review a systematic literature search was conducted and expert opinions of the guidelines group contributed also to the suggestions. Of 63 patients reported so far in the literature 59 had a beneficial outcome following DBS with moderate to marked tic improvement. However, randomized controlled studies including a larger number of patients are still lacking. Although persistent serious adverse effects (AEs) have hardly been reported, surgery-related (e.g., bleeding, infection) as well as stimulation-related AEs (e.g., sedation, anxiety, altered mood, changes in sexual function) may occur. At present time, DBS in TS is still in its infancy. Due to both different legality and practical facilities in different European countries these guidelines, therefore, have to be understood as recommendations of experts. However, among the ESSTS working group on DBS in TS there is general agreement that, at present time, DBS should only be used in adult, treatment resistant, and severely affected patients. It is highly recommended to perform DBS in the context of controlled trials. FAU - Muller-Vahl, Kirsten R AU - Muller-Vahl KR AD - Clinic of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. mueller-vahl.kirsten@mh-hannover.de FAU - Cath, Danielle C AU - Cath DC FAU - Cavanna, Andrea E AU - Cavanna AE FAU - Dehning, Sandra AU - Dehning S FAU - Porta, Mauro AU - Porta M FAU - Robertson, Mary M AU - Robertson MM FAU - Visser-Vandewalle, Veerle AU - Visser-Vandewalle V CN - ESSTS Guidelines Group LA - eng PT - Journal Article PT - Practice Guideline PT - Research Support, Non-U.S. Gov't PL - Germany TA - Eur Child Adolesc Psychiatry JT - European child & adolescent psychiatry JID - 9212296 SB - IM EIN - Eur Child Adolesc Psychiatry. 2011 Jul;20(7):377 MH - *Deep Brain Stimulation MH - Europe MH - Humans MH - Tic Disorders/*therapy MH - Tourette Syndrome/*therapy FIR - Androutsos, Christos IR - Androutsos C FIR - Aschauer, Harald IR - Aschauer H FIR - Baird, Gillian IR - Baird G FIR - Bos-Veneman, Netty IR - Bos-Veneman N FIR - Brambilla, Ariana IR - Brambilla A FIR - Cardona, Francesco IR - Cardona F FIR - Cath, Danielle C IR - Cath DC FIR - Cavanna, Andrea E IR - Cavanna AE FIR - Czernecki, Virginie IR - Czernecki V FIR - Dehning, Sandra IR - Dehning S FIR - Eapter, Alan IR - Eapter A FIR - Farkas, Luca IR - Farkas L FIR - Gadaros, Julia IR - Gadaros J FIR - Hartmann, Andreas IR - Hartmann A FIR - Hauser, Elizabeth IR - Hauser E FIR - Heyman, Isabel IR - Heyman I FIR - Hedderly, Tammy IR - Hedderly T FIR - Hoekstra, Pieter J IR - Hoekstra PJ FIR - Korsgaard, Anne IR - Korsgaard A FIR - Jackson, Georgina M IR - Jackson GM FIR - Larsson, Linnea IR - Larsson L FIR - Ludolph, Andrea G IR - Ludolph AG FIR - Martino, Davide IR - Martino D FIR - Menghetti, Claudia IR - Menghetti C FIR - Mol Debes, Nanette IR - Mol Debes N FIR - Muller, Norbert IR - Muller N FIR - Muller-Vahl, Kirsten IR - Muller-Vahl K FIR - Munchau, Alexander IR - Munchau A FIR - Murphy, Tara IR - Murphy T FIR - Musil, Richard IR - Musil R FIR - Nagy, Peter IR - Nagy P FIR - Nurnberger, Judith IR - Nurnberger J FIR - Oostra, Ben IR - Oostra B FIR - Paschou, Perry IR - Paschou P FIR - Pasquini, Massimo IR - Pasquini M FIR - Plessen, Kirsten J IR - Plessen KJ FIR - Porta, Mauro IR - Porta M FIR - Rickards, Hugh IR - Rickards H FIR - Rizzo, Renata IR - Rizzo R FIR - Robertson, Mary M IR - Robertson MM FIR - Roessner, Veit IR - Roessner V FIR - Rothenberger, Aribert IR - Rothenberger A FIR - Servello, Domenico IR - Servello D FIR - Skov, Liselotte IR - Skov L FIR - Stern, Jeremy S IR - Stern JS FIR - Strand, Gerd IR - Strand G FIR - Tarnok, Zsannett IR - Tarnok Z FIR - Termine, Cristiano IR - Termine C FIR - Van der Griendt, Jolande IR - Van der Griendt J FIR - Verdellen, Cara IR - Verdellen C FIR - Visser-Vandewalle, Veerle IR - Visser-Vandewalle V FIR - Wannag, Ebba IR - Wannag E FIR - Wolanczyck, Tomas IR - Wolanczyck T EDAT- 2011/03/30 06:00 MHDA- 2011/08/09 06:00 CRDT- 2011/03/30 06:00 PHST- 2011/03/30 06:00 [entrez] PHST- 2011/03/30 06:00 [pubmed] PHST- 2011/08/09 06:00 [medline] AID - 10.1007/s00787-011-0166-4 [doi] PST - ppublish SO - Eur Child Adolesc Psychiatry. 2011 Apr;20(4):209-17. doi: 10.1007/s00787-011-0166-4.