PMID- 21447109
OWN - NLM
STAT- MEDLINE
DCOM- 20110809
LR  - 20110330
IS  - 1479-8301 (Electronic)
IS  - 1346-3500 (Linking)
VI  - 11
IP  - 1
DP  - 2011 Mar
TI  - Clinical profiles of late-onset semantic dementia, compared with early-onset 
      semantic dementia and late-onset Alzheimer's disease.
PG  - 46-53
LID - 10.1111/j.1479-8301.2010.00351.x [doi]
AB  - BACKGROUND: Semantic dementia (SD) has been recognized as a representative of 
      dementia with presenile onset; however, recent epidemiological studies have shown 
      that SD also occurs in the elderly. There have been few studies about the 
      differences of clinical profiles between early-onset SD (EO-SD) and late-onset SD 
      (LO-SD). Age-associated changes in the brain might cause some additional 
      cognitive and behavioural profiles of LO-SD in contrast to the typical EO-SD 
      cases. The aim of the present study was to clarify the characteristics of 
      neuropsychological, and behavioural and psychological symptoms of dementia (BPSD) 
      profiles of LO-SD patients observed in screening tests in comparison with EO-SD 
      patients and late-onset Alzheimer's disease (LO-AD) patients as controls. 
      METHODS: Study participants were LO-SD (n = 10), EO-SD (n = 15) and LO-AD (n = 
      47). We examined the Mini-Mental State Examination (MMSE), the Raven's Coloured 
      Progressive Matrices (RCPM), the Short-Memory Questionnaire (SMQ), the 
      Neuropsychiatric Inventory (NPI) and the Stereotypy Rating Inventory (SRI). 
      RESULTS: Both SD groups scored significantly lower than the LO-AD patients in 
      'naming' of the MMSE. In the 'construction' score of the MMSE and the RCPM score, 
      however, the LO-SD patients as well as the LO-AD patients were significantly 
      lower than the EO-SD patients. In the SMQ score, 'euphoria' and 'disinhibition' 
      scores of the NPI, the SRI total and subscale scores, both SD groups were 
      significantly higher, whereas in the 'delusion' score of the NPI, both SD groups 
      were significantly lower than the LO-AD patients. CONCLUSIONS: Visuospatial and 
      constructive skills of LO-SD patients might be mildly deteriorated compared with 
      EO-SD patients, whereas other cognitive and behavioural profiles of LO-SD are 
      similar to EO-SD. Age-associated changes in the brain should be considered when 
      we diagnose SD in elderly patients.
CI  - (c) 2011 The Authors. Psychogeriatrics (c) 2011 Japanese Psychogeriatric Society.
FAU - Shimizu, Hideaki
AU  - Shimizu H
AD  - Department of Neuropsychiatry, Neuroscience, Ehime University Graduate School of 
      Medicine, Shitsukawa, Japan.
FAU - Komori, Kenjiro
AU  - Komori K
FAU - Fukuhara, Ryuji
AU  - Fukuhara R
FAU - Shinagawa, Shunichiro
AU  - Shinagawa S
FAU - Toyota, Yasutaka
AU  - Toyota Y
FAU - Kashibayashi, Tetsuo
AU  - Kashibayashi T
FAU - Sonobe, Naomi
AU  - Sonobe N
FAU - Matsumoto, Teruhisa
AU  - Matsumoto T
FAU - Mori, Takaaki
AU  - Mori T
FAU - Ishikawa, Tomohisa
AU  - Ishikawa T
FAU - Hokoishi, Kazuhiko
AU  - Hokoishi K
FAU - Tanimukai, Satoshi
AU  - Tanimukai S
FAU - Ueno, Shu-Ichi
AU  - Ueno S
FAU - Ikeda, Manabu
AU  - Ikeda M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Psychogeriatrics
JT  - Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society
JID - 101230058
SB  - IM
MH  - Age of Onset
MH  - Aged
MH  - Alzheimer Disease/diagnosis/psychology
MH  - Behavioral Symptoms
MH  - Case-Control Studies
MH  - Cognition
MH  - Diagnosis, Differential
MH  - Female
MH  - Frontotemporal Lobar Degeneration/*diagnosis/*psychology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Neuropsychological Tests
MH  - Stereotyped Behavior
EDAT- 2011/03/31 06:00
MHDA- 2011/08/10 06:00
CRDT- 2011/03/31 06:00
PHST- 2011/03/31 06:00 [entrez]
PHST- 2011/03/31 06:00 [pubmed]
PHST- 2011/08/10 06:00 [medline]
AID - 10.1111/j.1479-8301.2010.00351.x [doi]
PST - ppublish
SO  - Psychogeriatrics. 2011 Mar;11(1):46-53. doi: 10.1111/j.1479-8301.2010.00351.x.