PMID- 21447146
OWN - NLM
STAT- MEDLINE
DCOM- 20110915
LR  - 20211020
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 77
IP  - 6
DP  - 2011 Jun
TI  - Association of HLA alleles with Plasmodium falciparum severity in Malian 
      children.
PG  - 562-71
LID - 10.1111/j.1399-0039.2011.01661.x [doi]
AB  - Pre-erythrocytic immunity to Plasmodium falciparum malaria is likely to be 
      mediated by T-cell recognition of malaria epitopes presented on infected host 
      cells via class I and II major histocompatibility complex (MHC) antigens. To test 
      for associations of human leukocyte antigen (HLA) alleles with disease severity, 
      we performed high-resolution typing of HLA class I and II loci and compared the 
      distributions of alleles of HLA-A, -B, -C and -DRB1 loci in 359 Malian children 
      of Dogon ethnicity with uncomplicated or severe malaria. We observed that alleles 
      A*30:01 and A*33:01 had higher frequency in the group of patients with cerebral 
      disease compared to patients with uncomplicated disease [A*30:01: gf = 0.2031 vs 
      gf = 0.1064, odds ratio (OR) = 3.17, P = 0.004, confidence interval (CI) 
      (1.94-5.19)] and [A*33:01: gf = 0.0781 vs gf = 0.0266, 4.21, P = 0.005, CI 
      (1.89-9.84)], respectively. The A*30:01 and A*33:01 alleles share some sequence 
      motifs and A*30:01 appears to have a unique peptide binding repertoire compared 
      to other A*30 group alleles. Computer algorithms predicted malaria peptides with 
      strong binding affinity for HLA-A*30:01 and HLA-A*33:01 but not to closely 
      related alleles. In conclusion, we identified A*30:01 and A*33:01 as potential 
      susceptibility factors for cerebral malaria, providing further evidence that 
      polymorphism of MHC genes results in altered malaria susceptibility.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Lyke, K E
AU  - Lyke KE
AD  - Department of Medicine, Center for Vaccine Development, University of Maryland 
      School of Medicine, Baltimore, MD 21201, USA.
FAU - Fernandez-Vina, M A
AU  - Fernandez-Vina MA
FAU - Cao, K
AU  - Cao K
FAU - Hollenbach, J
AU  - Hollenbach J
FAU - Coulibaly, D
AU  - Coulibaly D
FAU - Kone, A K
AU  - Kone AK
FAU - Guindo, A
AU  - Guindo A
FAU - Burdett, L A
AU  - Burdett LA
FAU - Hartzman, R J
AU  - Hartzman RJ
FAU - Wahl, A R
AU  - Wahl AR
FAU - Hildebrand, W H
AU  - Hildebrand WH
FAU - Doumbo, O K
AU  - Doumbo OK
FAU - Plowe, C V
AU  - Plowe CV
FAU - Sztein, M B
AU  - Sztein MB
LA  - eng
GR  - HHMI/Howard Hughes Medical Institute/United States
GR  - U19 AI065683-05/AI/NIAID NIH HHS/United States
GR  - U19 AI065683/AI/NIAID NIH HHS/United States
GR  - N01AI85346/AI/NIAID NIH HHS/United States
GR  - N01-AI85346/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110330
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-A Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adolescent
MH  - Algorithms
MH  - Alleles
MH  - Child
MH  - Child, Preschool
MH  - Genetic Predisposition to Disease
MH  - HLA-A Antigens/*genetics
MH  - Histocompatibility Antigens Class II/*immunology
MH  - Humans
MH  - Infant
MH  - Interleukin-10/genetics
MH  - Leukocytes, Mononuclear/cytology
MH  - Malaria, Falciparum/genetics/*immunology
MH  - Mali
MH  - Odds Ratio
MH  - Plasmodium falciparum/*metabolism
MH  - Polymorphism, Genetic
PMC - PMC3152196
MID - NIHMS277801
EDAT- 2011/03/31 06:00
MHDA- 2011/09/16 06:00
CRDT- 2011/03/31 06:00
PHST- 2011/03/31 06:00 [entrez]
PHST- 2011/03/31 06:00 [pubmed]
PHST- 2011/09/16 06:00 [medline]
AID - 10.1111/j.1399-0039.2011.01661.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2011 Jun;77(6):562-71. doi: 10.1111/j.1399-0039.2011.01661.x. 
      Epub 2011 Mar 30.