PMID- 21447495
OWN - NLM
STAT- MEDLINE
DCOM- 20111215
LR  - 20151119
IS  - 1469-0756 (Electronic)
IS  - 0032-5473 (Linking)
VI  - 87
IP  - 1029
DP  - 2011 Jul
TI  - Serum resistin in acute myocardial infarction patients with and without diabetes 
      mellitus.
PG  - 463-7
LID - 10.1136/pgmj.2010.113571 [doi]
AB  - AIM: Human resistin is an adipokine, with a possible link to coronary heart 
      disease, and the relationship between serum resistin, insulin resistance, and 
      type 2 diabetes mellitus (T2DM) remains controversial. Therefore, this study 
      assessed serum resistin in patients with acute ST segment elevation myocardial 
      infarction (STEMI), with and without T2DM. METHODS: Between June 2009 and July 
      2010, 55 subjects were recruited into three groups: 20 non-diabetic patients with 
      acute STEMI (group 1), 20 diabetic patients with acute STEMI (group 2), and 15 
      healthy controls (group 3). Concentrations of serum lipids, fasting blood glucose 
      (FBG), insulin, troponin I, creatine kinase (CK), lactate dehydrogenase (LDH), 
      and resistin, were estimated. RESULTS: Concentrations of serum total cholesterol, 
      low density lipoprotein cholesterol, FBG, troponin I, CK, LDH, and resistin were 
      significantly higher in group 2 subjects, than in those in groups 1 and 3 
      (p<0.05). In group 2, serum resistin was positively correlated with serum 
      troponin I and triglycerides (r=0.59, p<0.05, and r=0.47, p<0.05, respectively), 
      but was negatively correlated with high density lipoprotein cholesterol (r=-0.46, 
      p<0.05). However, in this group, serum resistin was not correlated with age, 
      gender, body mass index (BMI), total cholesterol, FBG, insulin, CK, LDH, and the 
      calculated homeostasis model for insulin resistance (HOMA-IR) (p>0.05). Regarding 
      group 1, serum resistin was not correlated to any of these studied parameters 
      (p>0.05). CONCLUSIONS: Serum resistin concentrations are elevated in patients 
      with acute STEMI. This increase is more prominent in patients with T2DM than in 
      those without. However, serum resistin is not correlated with age, gender, BMI, 
      and insulin resistance. These data suggest that serum resistin concentration 
      might be used as a diagnostic biomarker for acute STEMI.
FAU - Korah, Tarek E
AU  - Korah TE
AD  - Department of Internal Medicine, Menoufiya University, Faculty of Medicine, 
      Shebin El-Koom, Menoufiya, Egypt. tarekkorah@yahoo.com
FAU - Ibrahim, Hesham H
AU  - Ibrahim HH
FAU - Badr, Eman A E
AU  - Badr EA
FAU - ElShafie, Maathir K
AU  - ElShafie MK
LA  - eng
PT  - Journal Article
DEP - 20110328
PL  - England
TA  - Postgrad Med J
JT  - Postgraduate medical journal
JID - 0234135
RN  - 0 (Biomarkers)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Resistin)
RN  - 0 (Troponin I)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - EC 2.7.3.2 (Creatine Kinase)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Cholesterol/blood
MH  - Cholesterol, LDL/blood
MH  - Creatine Kinase/blood
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Humans
MH  - L-Lactate Dehydrogenase/blood
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*blood
MH  - Resistin/*blood
MH  - Troponin I/blood
EDAT- 2011/03/31 06:00
MHDA- 2011/12/16 06:00
CRDT- 2011/03/31 06:00
PHST- 2011/03/31 06:00 [entrez]
PHST- 2011/03/31 06:00 [pubmed]
PHST- 2011/12/16 06:00 [medline]
AID - pgmj.2010.113571 [pii]
AID - 10.1136/pgmj.2010.113571 [doi]
PST - ppublish
SO  - Postgrad Med J. 2011 Jul;87(1029):463-7. doi: 10.1136/pgmj.2010.113571. Epub 2011 
      Mar 28.