PMID- 21448661
OWN - NLM
STAT- MEDLINE
DCOM- 20120224
LR  - 20111021
IS  - 1432-069X (Electronic)
IS  - 0340-3696 (Linking)
VI  - 303
IP  - 9
DP  - 2011 Nov
TI  - Autologous serum skin test response in chronic spontaneous urticaria and 
      respiratory diseases and its relationship with serum interleukin-18 level.
PG  - 643-9
LID - 10.1007/s00403-011-1144-x [doi]
AB  - Autologous serum skin test (ASST) is mostly used in chronic spontaneous urticaria 
      (CSU) to show autoreactivity. Interleukin-18 (IL-18) has also been shown to be 
      involved in autoimmune conditions. To investigate the role of autoreactivity 
      assessed by ASST in CSU and respiratory diseases and to investigate whether this 
      autoreactive state is related to IL-18 level or other clinical covariates. 
      Fifty-five patients with CSU (mean age: 40.3 +/- 12.3 years), 70 patients with 
      persistent asthma (mean age: 43.7 +/- 9.6 years), 21 patients with seasonal 
      allergic rhinitis (SAR) (mean age: 35.5 +/- 11.8 years) and 20 normal controls 
      (mean age: 37.7 +/- 9.8) were included. All subjects underwent a laboratory 
      examination and skin prick test. ASST was performed and serum IL-18 levels were 
      measured in all subjects. Positive response to ASST and serum IL-18 levels were 
      higher in CSU patients than those with respiratory diseases (asthma and SAR) 
      (P = 0.034 and 0.002, respectively) and normal controls (P = 0.004 and 0.031, 
      respectively). Considering all patients, IL-18 levels were higher in patients 
      with positive ASST (301.8 +/- 194.4 vs. 241.8 +/- 206.3 pg/ml, P = 0.036) than ASST 
      negative patients. ASST response was associated with disease severity in CSU 
      (P = 0.037) and asthma patients (P = 0.001). Multivariate analysis showed that 
      positive response to ASST was significantly associated with diagnosis of CSU (OR: 
      3.13, 95% CI: 1.25-7.87) and female gender (OR: 3.98, 95% CI: 1.19-13.38). ASST 
      response could be related with activity of the disease. A positive ASST response 
      found in respiratory diseases patients suggests that it may occur as a result of 
      some inflammatory events during the diseases' process.
FAU - Kurt, Emel
AU  - Kurt E
AD  - Department of Allergy, Eskisehir Osmangazi University, Eskisehir, Turkey. 
      dremelkurt@yahoo.com
FAU - Aktas, Ayse
AU  - Aktas A
FAU - Aksu, Kurtulus
AU  - Aksu K
FAU - Keren, Metin
AU  - Keren M
FAU - Dokumacioglu, Ali
AU  - Dokumacioglu A
FAU - Goss, Christopher H
AU  - Goss CH
FAU - Alatas, Ozkan
AU  - Alatas O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110330
PL  - Germany
TA  - Arch Dermatol Res
JT  - Archives of dermatological research
JID - 8000462
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adult
MH  - Asthma/*diagnosis/immunology/pathology/physiopathology
MH  - Autoimmunity
MH  - Chronic Disease
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Interleukin-18/*blood
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Rhinitis, Allergic, Seasonal/*diagnosis/immunology/pathology/physiopathology
MH  - Risk Factors
MH  - Serum
MH  - *Sex Factors
MH  - Skin Tests
MH  - *Urticaria
EDAT- 2011/03/31 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/03/31 06:00
PHST- 2010/12/29 00:00 [received]
PHST- 2011/02/24 00:00 [accepted]
PHST- 2011/02/16 00:00 [revised]
PHST- 2011/03/31 06:00 [entrez]
PHST- 2011/03/31 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1007/s00403-011-1144-x [doi]
PST - ppublish
SO  - Arch Dermatol Res. 2011 Nov;303(9):643-9. doi: 10.1007/s00403-011-1144-x. Epub 
      2011 Mar 30.