PMID- 21448964
OWN - NLM
STAT- MEDLINE
DCOM- 20110809
LR  - 20131121
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 33
IP  - 4
DP  - 2011 Apr
TI  - T(2) -weighted STIR imaging of myocardial edema associated with 
      ischemia-reperfusion injury: the influence of proton density effect on image 
      contrast.
PG  - 962-7
LID - 10.1002/jmri.22456 [doi]
AB  - PURPOSE: To investigate the contribution of proton density (PD) in T(2) -STIR 
      based edema imaging in the setting of acute myocardial infarction (AMI). 
      MATERIALS AND METHODS: Canines (n = 5), subjected to full occlusion of the left 
      anterior descending artery for 3 hours, underwent serial magnetic resonance 
      imaging (MRI) studies 2 hours postreperfusion (day 0) and on day 2. During each 
      study, T(1) and T(2) maps, STIR (TE = 7.1 msec and 64 msec) and late gadolinium 
      enhancement (LGE) images were acquired. Using T(1) and T(2) maps, relaxation and 
      PD contributions to myocardial edema contrast (EC) in STIR images at both TEs 
      were calculated. RESULTS: Edematous territories showed significant increase in PD 
      (20.3 +/- 14.3%, P < 0.05) relative to healthy territories. The contributions of 
      T(1) changes and T(2) or PD changes toward EC were in opposite directions. 
      One-tailed t-test confirmed that the mean T(2) and PD-based EC at both TEs were 
      greater than zero. EC from STIR images at TE = 7.1 msec was dominated by PD than 
      T(2) effects (94.3 +/- 11.3% vs. 17.6 +/- 2.5%, P < 0.05), while at TE = 64 msec, 
      T(2) effects were significantly greater than PD effects (90.8 +/- 20.3% vs. 12.5 +/- 
      11.9%, P < 0.05). The contribution from PD in standard STIR acquisitions (TE = 64 
      msec) was significantly higher than 0 (P < 0.05). CONCLUSION: In addition to T(2) 
      -weighting, edema detection in the setting of AMI with T(2) -weighted STIR 
      imaging has a substantial contribution from PD changes, likely stemming from 
      increased free-water content within the affected tissue. This suggests that 
      imaging approaches that take advantage of both PD as well as T(2) effects may 
      provide the optimal sensitivity for detecting myocardial edema.
CI  - Copyright (c) 2011 Wiley-Liss, Inc.
FAU - Zhou, Xiangzhi
AU  - Zhou X
AD  - Department of Radiology, Northwestern University, Chicago, IL, USA.
FAU - Rundell, Veronica
AU  - Rundell V
FAU - Liu, Ying
AU  - Liu Y
FAU - Tang, Richard
AU  - Tang R
FAU - Klein, Rachel
AU  - Klein R
FAU - Shah, Saurabh
AU  - Shah S
FAU - Zuehlsdorff, Sven
AU  - Zuehlsdorff S
FAU - Tsaftaris, Sotirios A
AU  - Tsaftaris SA
FAU - Li, Debiao
AU  - Li D
FAU - Dharmakumar, Rohan
AU  - Dharmakumar R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
RN  - 0 (Contrast Media)
RN  - 0 (Protons)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Animals
MH  - Contrast Media/pharmacology
MH  - Dogs
MH  - Edema
MH  - Female
MH  - Gadolinium/pharmacology
MH  - Image Processing, Computer-Assisted/*methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Models, Biological
MH  - Models, Statistical
MH  - Myocardial Infarction/pathology
MH  - Myocardium/*pathology
MH  - Protons
MH  - Reperfusion Injury/*pathology
EDAT- 2011/03/31 06:00
MHDA- 2011/08/10 06:00
CRDT- 2011/03/31 06:00
PHST- 2011/03/31 06:00 [entrez]
PHST- 2011/03/31 06:00 [pubmed]
PHST- 2011/08/10 06:00 [medline]
AID - 10.1002/jmri.22456 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2011 Apr;33(4):962-7. doi: 10.1002/jmri.22456.