PMID- 21449921
OWN - NLM
STAT- MEDLINE
DCOM- 20120213
LR  - 20111011
IS  - 1651-2227 (Electronic)
IS  - 0803-5253 (Linking)
VI  - 100
IP  - 11
DP  - 2011 Nov
TI  - The effect of neutral and acidic oligosaccharides on stool viscosity, stool 
      frequency and stool pH in preterm infants.
PG  - 1426-31
LID - 10.1111/j.1651-2227.2011.02295.x [doi]
AB  - AIM: To determine the effect of neutral oligosaccharides [small-chain 
      galacto-oligosaccharides/long-chain fructo-oligosaccharides (scGOS/lcFOS)] in 
      combination with acidic oligosaccharides (pAOS) on stool viscosity, stool 
      frequency and stool pH in preterm infants. METHODS: In this explorative RCT, 
      preterm infants with gestational age <32 weeks and/or birth weight <1500 g 
      received enteral supplementation with scGOS/lcFOS/pAOS or placebo (maltodextrin) 
      between days 3 and 30 of life. Stool samples were collected at day 30 after 
      birth. RESULTS: In total, 113 infants were included. Baseline and nutritional 
      characteristics were not different between both groups. Stool viscosity at day 30 
      was lower in the prebiotics group (16.8N) (3.9-67.8) compared with the placebo 
      group (26.3N) (1.3-148.0) (p = 0.03; 95% CI -0.80 to 0.03). There was a trend 
      towards higher stool frequency in the prebiotics group (3.1 +/- 0.8) compared with 
      the placebo group (2.8 +/- 0.7) (p = 0.15; 95% CI -0.08 to 0.52). Stool pH at day 
      30 was lower in the in the prebiotics group (5.9 +/- 0.6) compared with the placebo 
      group (6.2 +/- 0.3) (p = 0.009; 95% CI 0.08 to 0.53). CONCLUSIONS: Enteral 
      supplementation of a prebiotic mixture consisting of neutral (scGOS/lcFOS) and 
      acidic oligosaccharides (pAOS) decreases stool viscosity and stool pH with a 
      trend towards increased stool frequency in preterm infants. The inclusion of pAOS 
      in a formula containing a mixture of scGOS/lcFOS does not add specific advantages 
      to the formula in terms of stool viscosity, frequency, pH as well as feeding 
      tolerance.
CI  - (c) 2011 The Author(s)/Acta Paediatrica (c) 2011 Foundation Acta Paediatrica.
FAU - Westerbeek, E A M
AU  - Westerbeek EA
AD  - Department of Neonatology, VU University Medical Center, Amsterdam, the 
      Netherlands. rm.vanelburg@vumc.nl
FAU - Hensgens, R L
AU  - Hensgens RL
FAU - Mihatsch, W A
AU  - Mihatsch WA
FAU - Boehm, G
AU  - Boehm G
FAU - Lafeber, H N
AU  - Lafeber HN
FAU - van Elburg, R M
AU  - van Elburg RM
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20110425
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
RN  - 0 (Oligosaccharides)
RN  - 0 (Prebiotics)
SB  - IM
MH  - Defecation/physiology
MH  - Enteral Nutrition
MH  - Feces/*chemistry
MH  - Gastrointestinal Transit/*physiology
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Infant Formula/chemistry/standards
MH  - Infant, Newborn
MH  - Infant, Premature/physiology
MH  - Infant, Very Low Birth Weight/physiology
MH  - Intensive Care Units, Neonatal
MH  - Milk, Human/chemistry
MH  - Netherlands
MH  - Oligosaccharides/administration & dosage/physiology/*therapeutic use
MH  - Prebiotics
MH  - Viscosity
EDAT- 2011/04/01 06:00
MHDA- 2012/02/14 06:00
CRDT- 2011/04/01 06:00
PHST- 2011/04/01 06:00 [entrez]
PHST- 2011/04/01 06:00 [pubmed]
PHST- 2012/02/14 06:00 [medline]
AID - 10.1111/j.1651-2227.2011.02295.x [doi]
PST - ppublish
SO  - Acta Paediatr. 2011 Nov;100(11):1426-31. doi: 10.1111/j.1651-2227.2011.02295.x. 
      Epub 2011 Apr 25.