PMID- 21451105
OWN - NLM
STAT- MEDLINE
DCOM- 20110826
LR  - 20200930
IS  - 1522-1563 (Electronic)
IS  - 0363-6143 (Linking)
VI  - 300
IP  - 6
DP  - 2011 Jun
TI  - Ca2+ signaling in the regulation of dendritic cell functions.
PG  - C1205-14
LID - 10.1152/ajpcell.00039.2011 [doi]
AB  - Dendritic cells (DCs) are highly versatile antigen-presenting cells critically 
      involved in both innate and adaptive immunity as well as maintenance of 
      self-tolerance. DC function is governed by Ca(2+) signaling, which directs the DC 
      responses to diverse antigens, including Toll-like receptor ligands, intact 
      bacteria, and microbial toxins. Ca(2+)-sensitive DC functions include DC 
      activation, maturation, migration, and formation of immunological synapses with T 
      cells. Moreover, alterations of cytosolic Ca(2+) trigger immune suppression or 
      switch off DC activity. Ca(2+) signals are generated by the orchestration of 
      Ca(2+) transport processes across plasma, endoplasmic reticulum, and inner 
      mitochondrial membrane. These processes include active pumping of Ca(2+), 
      Ca(2+)/Na(+) antiport, and electrodiffusion through Ca(2+)-permeable channels or 
      uniporters. Ca(2+) channels in the plasma membrane such as Ca(2+) 
      release-activated Ca(2+) or L-type Ca(2+) channels are tightly regulated by the 
      membrane potential which in turn depends on the activity of voltage-gated K(+) or 
      Ca(2+)-activated nonselective cation channels. The rapidly growing knowledge on 
      the function and regulation of these membrane transport proteins provides novel 
      insight into pathophysiological mechanisms underlying dysfunction of the immune 
      system and opens novel therapeutic opportunity to favorably influence the 
      function of the immune system.
FAU - Shumilina, Ekaterina
AU  - Shumilina E
AD  - Department of Physiology, University of Tubingen, Gmelinstrasse 5, Tubingen, 
      Germany. ekaterina.shumilina@uni-tuebingen.de
FAU - Huber, Stephan M
AU  - Huber SM
FAU - Lang, Florian
AU  - Lang F
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110330
PL  - United States
TA  - Am J Physiol Cell Physiol
JT  - American journal of physiology. Cell physiology
JID - 100901225
RN  - 0 (Ion Channels)
RN  - 0 (Membrane Transport Proteins)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Calcium/*metabolism
MH  - Calcium Signaling/*immunology
MH  - Cell Differentiation
MH  - Dendritic Cells/cytology/*immunology/*physiology
MH  - Humans
MH  - Ion Channels/metabolism
MH  - Membrane Transport Proteins/metabolism
MH  - T-Lymphocytes/immunology
EDAT- 2011/04/01 06:00
MHDA- 2011/08/30 06:00
CRDT- 2011/04/01 06:00
PHST- 2011/04/01 06:00 [entrez]
PHST- 2011/04/01 06:00 [pubmed]
PHST- 2011/08/30 06:00 [medline]
AID - ajpcell.00039.2011 [pii]
AID - 10.1152/ajpcell.00039.2011 [doi]
PST - ppublish
SO  - Am J Physiol Cell Physiol. 2011 Jun;300(6):C1205-14. doi: 
      10.1152/ajpcell.00039.2011. Epub 2011 Mar 30.