PMID- 21452254
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20220409
IS  - 2151-4658 (Electronic)
IS  - 2151-464X (Print)
IS  - 2151-464X (Linking)
VI  - 63
IP  - 7
DP  - 2011 Jul
TI  - Health-related quality of life in patients with newly diagnosed antineutrophil 
      cytoplasmic antibody-associated vasculitis.
PG  - 1055-61
LID - 10.1002/acr.20471 [doi]
AB  - OBJECTIVE: Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) can 
      present with a broad spectrum of signs and symptoms. The relative effects of 
      different manifestations on health-related quality of life (HRQOL) are unknown. 
      METHODS: We conducted an individual patient data meta-analysis of baseline Short 
      Form 36 (SF-36) scores from 4 randomized controlled trials of patients with newly 
      diagnosed AAV. We determined the associations between organ manifestations at 
      trial entry and the SF-36 physical composite score (PCS) and mental composite 
      score (MCS) using mixed-effects models adjusted for demographic factors. 
      Associations with each of the 8 domains of the SF-36 were further explored using 
      multivariate multiple regression. RESULTS: SF-36 data were available from 346 
      patients. Older age (-0.11 points/year [95% confidence interval (95% CI) -0.21, 
      -0.012]; P = 0.029) and neurologic involvement (-5.84 points; P < 0.001) at 
      baseline were associated with lower PCS. Physical functioning scores were the 
      most affected and older age scores (-0.25 points/year [95% CI -0.38, -0.11]; P < 
      0.001) and neurologic involvement (-8.48 points [95% CI -12.90, -4.06]; P < 
      0.001) had the largest effects. The MCS was negatively affected only by chest 
      involvement (P = 0.027), but this effect was not exerted in any particular 
      domain. CONCLUSION: In patients with newly diagnosed AAV, HRQOL is complex and 
      incompletely explained by their organ system manifestations.
CI  - Copyright (c) 2011 by the American College of Rheumatology.
FAU - Walsh, Michael
AU  - Walsh M
AD  - McMaster University, Hamilton, Ontario, Canada. mwwalsh@ucalgary.ca
FAU - Mukhtyar, Chetan
AU  - Mukhtyar C
FAU - Mahr, Alfred
AU  - Mahr A
FAU - Herlyn, Karen
AU  - Herlyn K
FAU - Luqmani, Raashid
AU  - Luqmani R
FAU - Merkel, Peter A
AU  - Merkel PA
FAU - Jayne, David R W
AU  - Jayne DR
LA  - eng
GR  - U01 AR051874/AR/NIAMS NIH HHS/United States
GR  - CAPMC/CIHR/Canada
GR  - U54 RR019497/RR/NCRR NIH HHS/United States
GR  - U01 AR051874-04/AR/NIAMS NIH HHS/United States
GR  - U54 AR057319-08/AR/NIAMS NIH HHS/United States
GR  - U54AR057319/AR/NIAMS NIH HHS/United States
GR  - R01 FD003516/FD/FDA HHS/United States
GR  - U54RR019497/RR/NCRR NIH HHS/United States
GR  - U54 AR057319/AR/NIAMS NIH HHS/United States
GR  - R01-FD003516-01/FD/FDA HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arthritis Care Res (Hoboken)
JT  - Arthritis care & research
JID - 101518086
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnosis/*psychology
MH  - Antibodies, Antineutrophil Cytoplasmic
MH  - Female
MH  - Health Status
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Quality of Life/*psychology
MH  - Self Report
MH  - Surveys and Questionnaires
PMC - PMC3128179
MID - NIHMS280548
EDAT- 2011/04/01 06:00
MHDA- 2011/09/02 06:00
PMCR- 2012/07/01
CRDT- 2011/04/01 06:00
PHST- 2011/04/01 06:00 [entrez]
PHST- 2011/04/01 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
PHST- 2012/07/01 00:00 [pmc-release]
AID - 10.1002/acr.20471 [doi]
PST - ppublish
SO  - Arthritis Care Res (Hoboken). 2011 Jul;63(7):1055-61. doi: 10.1002/acr.20471.