PMID- 21452674
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20190918
IS  - 0042-8450 (Print)
IS  - 0042-8450 (Linking)
VI  - 68
IP  - 2
DP  - 2011 Feb
TI  - Multinucleated stromal giant cells in adenoid cystic carcinoma of the breast: a 
      case report and literature review.
PG  - 178-80
AB  - BACKGROUND: We presented an unusual case of adenoid cystic carcinoma (ACC) of the 
      breast with multinucleated stromal giant cells (MSGCs). To the best of our 
      knowledge, the occurrence of ACC with MSGCs has not been reported previously. 
      MSGCs should be distinguished from other multinucleated giant cells in breast 
      tumors. The histogenesis of MSGCs still remains obscure. In hope to elucidate the 
      histogenesis of MSGCs, we used a broad range of antibodies. CASE REPORT: A 
      40-year-old woman presented with a palpable lump in the subareolar location of 
      her right breast. Excision of the tumor was performed. At gross pathologic 
      examination the tumor was 20 x 15 x 15 mm in size, red-brown and well 
      circumscribed. The surgical margins were positive for carcinoma and skin-sparing 
      mastectomy with axillary dissection was complited. Eighteen lymph nodes examined 
      were uninvolved. Pathohistological examination showed ACC with numerous MSGCs 
      scattered within tumor stroma. Immunohistochemical studies indicated that MSGCs 
      are probably derived from stromal fibroblasts. These cells showed strong 
      reactivity only for vimentin. Staining for histiocytic marker (CD68), as well as 
      for epithelial marker (cytokeratin), myoepithelial markers (S-100, alpha-smooth 
      muscle actin), vascular marker (CD34), hormonal receptors (ER, PR) and HER2 in 
      MSGCs were negative. CONCLUSION: The presence of MSGCs should not alter the 
      prognosis of an otherwise typical breast ACC.
FAU - Milentijevic, Maja Jovicic
AU  - Milentijevic MJ
AD  - University of Nis, School of Medicine, Institute of Pathology, Nis, Serbia. 
      majajmi@gmail.com
FAU - Basic, Marin
AU  - Basic M
FAU - Petrovic, Aleksandar
AU  - Petrovic A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Serbia
TA  - Vojnosanit Pregl
JT  - Vojnosanitetski pregled
JID - 21530700R
SB  - IM
MH  - Adult
MH  - Breast Neoplasms/chemistry/*pathology
MH  - Carcinoma, Adenoid Cystic/chemistry/*pathology
MH  - Female
MH  - Giant Cells/*pathology
MH  - Humans
MH  - Stromal Cells/*pathology
EDAT- 2011/04/02 06:00
MHDA- 2011/05/25 06:00
CRDT- 2011/04/02 06:00
PHST- 2011/04/02 06:00 [entrez]
PHST- 2011/04/02 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
AID - 10.2298/vsp1102178j [doi]
PST - ppublish
SO  - Vojnosanit Pregl. 2011 Feb;68(2):178-80. doi: 10.2298/vsp1102178j.