PMID- 21454005
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20151119
IS  - 1579-2129 (Electronic)
IS  - 0300-2896 (Linking)
VI  - 47
IP  - 4
DP  - 2011 Apr
TI  - Molecular mechanisms of inflammation during exacerbations of chronic obstructive 
      pulmonary disease.
PG  - 176-83
LID - 10.1016/j.arbres.2010.12.003 [doi]
AB  - INTRODUCTION: Exacerbations of chronic obstructive pulmonary disease (COPD) are 
      characterised by an inflammatory and systemic response that persists for some 
      time after their clinical resolution. The mechanisms of this inflammatory process 
      are not well known. OBJECTIVES: To explore the inflammatory changes and possible 
      mechanisms during COPD exacerbation. METHODS: We determined the inflammatory cell 
      concentrations in blood and sputum, nitric oxide in exhaled air (FeNO), 
      C-reactive protein (CRP) in plasma, cytokines (IL-6, 8, 1beta, 10, 12, TNF-alpha) and 
      SLPI (leukocyte protease inhibitor) and total antioxidant status (TAS) in blood 
      and sputum, the activity of nuclear kappa B factor (NF-kappa B) and of the histone 
      deacetylase enzyme (HDAC) in 17 patients during COPD exacerbation and in stable 
      phase, as well as in 17 smoker and 11 non-smoker controls. RESULTS: COPD 
      exacerbations are characterised by high levels of FeNO (p<0.05), plasma CRP 
      (p<0.001) and IL-8, IL-1B, IL-10 in sputum (p<0.05) greater activation of NF-kappa 
      appaB in sputum macrophages compared with stable COPD and controls. During the 
      stable phase, there continue to be high levels of oxidative stress, SLPI, IL-8, 
      IL-6 and TNF-alfa, with no observed changes in either HDAC activity or in the 
      amount of neutrophils in sputum, despite presenting a significant improvement 
      (p<0.05) in lung function. CONCLUSIONS: Changes were observed in different 
      pulmonary and systemic inflammatory markers during COPD exacerbation, which did 
      not completely resolve during stable phase. However, current treatment does not 
      allow for HDAC activity to be modified, which limits its anti-inflammatory 
      effects.
CI  - Copyright (c) 2010 SEPAR. Published by Elsevier Espana. All rights reserved.
FAU - Kersul, Ana L
AU  - Kersul AL
AD  - Servicio de Neumologia, Hospital Universitario Son Dureta, Palma de Mallorca, 
      Spain.
FAU - Iglesias, Amanda
AU  - Iglesias A
FAU - Rios, Angel
AU  - Rios A
FAU - Noguera, Aina
AU  - Noguera A
FAU - Forteza, Aina
AU  - Forteza A
FAU - Serra, Enrique
AU  - Serra E
FAU - Agusti, Alvar
AU  - Agusti A
FAU - Cosio, Borja G
AU  - Cosio BG
LA  - eng
PT  - Journal Article
DEP - 20110331
PL  - Spain
TA  - Arch Bronconeumol
JT  - Archivos de bronconeumologia
JID - 0354720
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (NF-kappa B)
RN  - 0 (SLPI protein, human)
RN  - 0 (Secretory Leukocyte Peptidase Inhibitor)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.5.1.98 (Histone Deacetylases)
SB  - IM
MH  - Aged
MH  - Antioxidants/analysis
MH  - Biomarkers
MH  - Blood Cells/pathology
MH  - Breath Tests
MH  - C-Reactive Protein/analysis
MH  - Cytokines/blood
MH  - Female
MH  - Gene Expression Regulation
MH  - Histone Deacetylases/blood
MH  - Humans
MH  - Inflammation/*metabolism
MH  - Macrophages/metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - NF-kappa B/*metabolism
MH  - Nitric Oxide/analysis
MH  - Oxidative Stress
MH  - Pulmonary Disease, Chronic Obstructive/*metabolism/physiopathology
MH  - Secretory Leukocyte Peptidase Inhibitor/blood
MH  - Smoking/metabolism
MH  - Spirometry
MH  - Sputum/chemistry/cytology
MH  - Transcription, Genetic
EDAT- 2011/04/02 06:00
MHDA- 2011/08/24 06:00
CRDT- 2011/04/02 06:00
PHST- 2010/07/22 00:00 [received]
PHST- 2010/12/04 00:00 [revised]
PHST- 2010/12/13 00:00 [accepted]
PHST- 2011/04/02 06:00 [entrez]
PHST- 2011/04/02 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
AID - S0300-2896(11)00027-5 [pii]
AID - 10.1016/j.arbres.2010.12.003 [doi]
PST - ppublish
SO  - Arch Bronconeumol. 2011 Apr;47(4):176-83. doi: 10.1016/j.arbres.2010.12.003. Epub 
      2011 Mar 31.