PMID- 21454205
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20111209
IS  - 2152-2669 (Electronic)
IS  - 2152-2669 (Linking)
VI  - 11
IP  - 1
DP  - 2011 Feb
TI  - High-throughput genomic analysis in Waldenstrom's macroglobulinemia.
PG  - 106-8
LID - 10.3816/CLML.2011.n.021 [doi]
AB  - Single-nucleotide polymorphism array (SNPa) and array-based comparative genomic 
      hybridization (aCGH) are among the most sensitive genomic high-throughput 
      screening techniques used in the exploration of genetic abnormalities in 
      Waldenstrom's macroglobulinemia (WM). SNP and aCGH allow the identification of 
      copy number abnormalities (CNA) at the kilobase level thus identifying cryptic 
      genetic abnormalities unseen by lower-resolution approaches such as conventional 
      cytogenetic or fluorescence in situ hybridization (FISH). CNA were identified in 
      nearly 80% of cases by aCGH that delineated in addition minimal altered regions. 
      At gene level, remarkable findings affecting genes involved in the regulation of 
      the NF-kB signaling pathways were identified, such as biallelic inactivation of 
      TNFAIP3 and TRAF3. SNPa also allowed characterization of copy neutral losses such 
      as uniparental disomies (UPD), which is an important and frequent mechanism of 
      gene alteration in cancer cells. Herein, we summarize the current knowledge of WM 
      genomic basis using these high-throughput techniques.
FAU - Poulain, Stephanie
AU  - Poulain S
AD  - UF de Biologie Moleculaire, CH de Valenciennes, Valenciennes, France.
FAU - Braggio, Esteban
AU  - Braggio E
FAU - Roumier, Christophe
AU  - Roumier C
FAU - Aijjou, Rachid
AU  - Aijjou R
FAU - Broucqsault, Natacha
AU  - Broucqsault N
FAU - Galiegue-Zouitina, Sylvie
AU  - Galiegue-Zouitina S
FAU - Manier, Salomon
AU  - Manier S
FAU - Soenen, Valerie
AU  - Soenen V
FAU - Nibourel, Olivier
AU  - Nibourel O
FAU - Duthilleul, Patrick
AU  - Duthilleul P
FAU - Fonseca, Rafael
AU  - Fonseca R
FAU - Leleu, Xavier
AU  - Leleu X
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Clin Lymphoma Myeloma Leuk
JT  - Clinical lymphoma, myeloma & leukemia
JID - 101525386
SB  - IM
MH  - Comparative Genomic Hybridization
MH  - Female
MH  - Genome, Human
MH  - Humans
MH  - Male
MH  - Polymorphism, Single Nucleotide
MH  - Protein Array Analysis
MH  - Waldenstrom Macroglobulinemia/*genetics
EDAT- 2011/04/02 06:00
MHDA- 2011/08/31 06:00
CRDT- 2011/04/02 06:00
PHST- 2011/04/02 06:00 [entrez]
PHST- 2011/04/02 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
AID - S2152-2650(11)70142-2 [pii]
AID - 10.3816/CLML.2011.n.021 [doi]
PST - ppublish
SO  - Clin Lymphoma Myeloma Leuk. 2011 Feb;11(1):106-8. doi: 10.3816/CLML.2011.n.021.