PMID- 21457541
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1755-8166 (Electronic)
IS  - 1755-8166 (Linking)
VI  - 4
IP  - 1
DP  - 2011 Apr 1
TI  - A rare case of t(11;22) in a mantle cell lymphoma like B-cell neoplasia resulting 
      in a fusion of IGL and CCND1: case report.
PG  - 8
LID - 10.1186/1755-8166-4-8 [doi]
AB  - The chromosomal translocation (11;14)(q13;q32) rearranging the locus for cyclin 
      D1 (CCND1) to that of the immunoglobulin heavy chain (IGH) can be found in 
      virtually all cases of mantle cell lymphoma (MCL), while other CCND1 
      translocations are extremely rare. As CCND1 overexpression and activation is a 
      hallmark of MCL it is regarded as a central biological mechanism in the 
      development and maintenance of this disease.Here we present a patient initially 
      diagnosed with chronic lymphocytic leukemia (CLL) where chromosome banding 
      analysis revealed, among other aberrations, a translocation (11;22)(q13;q11.2). 
      We show by fluorescence in situ hybridization (FISH) analysis that on chromosome 
      22 the immunoglobulin light chain lambda (IGL) is involved in this cytogenetic 
      aberration. Additionally, we demonstrate the resulting overexpression of CCND1 on 
      the RNA and protein level, thereby consolidating the new diagnosis of a MCL-like 
      B-cell neoplasia. Summing up, we described a rare case of t(11;22)(q13;q11.2) in 
      a MCL-like neoplasia and showed that this aberration leads to an overexpression 
      of CCND1 which is regarded as a key biological feature in MCL. This case 
      underlines the importance of cytogenetic analyses especially in atypical cases of 
      B cell lymphomas.
FAU - Rocha, Cristiano Krings
AU  - Rocha CK
AD  - Department I of Internal Medicine, University at Cologne, Cologne, Germany. 
      karl-anton.kreuzer@uni-koeln.de.
FAU - Praulich, Inka
AU  - Praulich I
FAU - Gehrke, Iris
AU  - Gehrke I
FAU - Hallek, Michael
AU  - Hallek M
FAU - Kreuzer, Karl-Anton
AU  - Kreuzer KA
LA  - eng
PT  - Journal Article
DEP - 20110401
PL  - England
TA  - Mol Cytogenet
JT  - Molecular cytogenetics
JID - 101317942
PMC - PMC3077317
EDAT- 2011/04/05 06:00
MHDA- 2011/04/05 06:01
PMCR- 2011/04/01
CRDT- 2011/04/05 06:00
PHST- 2010/12/10 00:00 [received]
PHST- 2011/04/01 00:00 [accepted]
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2011/04/05 06:01 [medline]
PHST- 2011/04/01 00:00 [pmc-release]
AID - 1755-8166-4-8 [pii]
AID - 10.1186/1755-8166-4-8 [doi]
PST - epublish
SO  - Mol Cytogenet. 2011 Apr 1;4(1):8. doi: 10.1186/1755-8166-4-8.