PMID- 21458024
OWN - NLM
STAT- MEDLINE
DCOM- 20110707
LR  - 20240109
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Print)
IS  - 0045-6535 (Linking)
VI  - 83
IP  - 10
DP  - 2011 May
TI  - Levels of persistent organic pollutant and their predictors among young adults.
PG  - 1374-82
LID - 10.1016/j.chemosphere.2011.02.071 [doi]
AB  - Exposure to persistent organic pollutants (POPs), such as polychlorinated 
      biphenyls (PCBs), dichlorodiphenyldichloroethane (p,p'-DDE), and 
      hexachlorobenzene (HCB) continues to be of concern due to their ubiquitous 
      distribution and high persistence. Current toxicant body burden is still a 
      primary concern within the Akwesasne Mohawk Nation since other studies conducted 
      within the community have shown relationships between these POPs and endocrine 
      disruption. In this article we describe the levels of these toxicants in young 
      adults of the Akwesasne Mohawk Nation between the ages of 17 and 21 years of age 
      (mean age 18.1 years), and investigate potential influences of their current body 
      burden. Seventeen congeners in fourteen chromatographic peaks were detected in 
      50% or more of the individuals sampled (geometric mean [GM] of the sum of these 
      congeners=0.43 ppb). Congeners 118, 138[+163+164] and 153 had the highest rate of 
      detection (>/=98%) within the Akwesasne young adults. Of the other organochlorines, 
      HCB (GM=0.04 ppb) and p,p'-DDE (GM=0.38 ppb) were found in 100% and 99% of the 
      sample respectively. Significantly higher levels of PCBs were found among 
      individuals who were breastfed as infants, were first born, or had consumed local 
      fish within the past year. When compared to levels of p,p'-DDE, HCB, and 13 
      specific congeners reported by the CDC for youth between the ages of 12 and 19 
      years, the geometric means of several congeners (CBs 99, 105, 110, and 118) among 
      the Akwesasne were higher than the reported CDC 90th percentile. In contrast, 
      levels of CB 28 in Akwesasne young adults were ~50% or less than those of the CDC 
      cohort. p,p'-DDE and HCB levels were generally higher in the CDC cohort (GM of 
      0.516 and 0.065 ppb, respectively for Mohawks vs. 2.51 and 0.123, respectively, 
      for CDC). Concentrations of non-persistent PCBs among this sample of Akwesasne 
      young adults were higher than those reported by the CDC suggesting continued 
      exposure, but lower than those associated with severe contamination. Additional 
      research into the concentration trends of individual PCB congeners within 
      Akwesasne youth and young adults is warranted to further improve our insight into 
      the determinants and influences of organochlorine concentrations within members 
      of the Akwesasne community.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Gallo, Mia V
AU  - Gallo MV
AD  - University at Albany, Center for the Elimination of Minority Health Disparities, 
      A&S 237, Albany, NY, United States. mvgallo@albany.edu
FAU - Schell, Lawrence M
AU  - Schell LM
FAU - DeCaprio, Anthony P
AU  - DeCaprio AP
FAU - Jacobs, Agnes
AU  - Jacobs A
LA  - eng
GR  - P20 MD003373/MD/NIMHD NIH HHS/United States
GR  - R01 ES010904/ES/NIEHS NIH HHS/United States
GR  - ESO4913-10/PHS HHS/United States
GR  - R01 ES010904-05/ES/NIEHS NIH HHS/United States
GR  - ES10904-06/ES/NIEHS NIH HHS/United States
GR  - P20 MD003373-03/MD/NIMHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110401
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Environmental Pollutants)
RN  - 0 (Organic Chemicals)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - V14159DF29 (Dichlorodiphenyldichloroethane)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Behavior
MH  - Body Burden
MH  - Breast Feeding/epidemiology
MH  - Demography
MH  - Dichlorodiphenyldichloroethane/blood
MH  - Environmental Exposure/analysis/standards/*statistics & numerical data
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Humans
MH  - Indians, North American
MH  - Male
MH  - Organic Chemicals/*blood
MH  - Polychlorinated Biphenyls/blood
MH  - Risk Factors
MH  - Young Adult
PMC - PMC3095889
MID - NIHMS285870
EDAT- 2011/04/05 06:00
MHDA- 2011/07/08 06:00
PMCR- 2012/05/01
CRDT- 2011/04/05 06:00
PHST- 2010/08/06 00:00 [received]
PHST- 2011/01/07 00:00 [revised]
PHST- 2011/02/27 00:00 [accepted]
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2011/07/08 06:00 [medline]
PHST- 2012/05/01 00:00 [pmc-release]
AID - S0045-6535(11)00235-9 [pii]
AID - 10.1016/j.chemosphere.2011.02.071 [doi]
PST - ppublish
SO  - Chemosphere. 2011 May;83(10):1374-82. doi: 10.1016/j.chemosphere.2011.02.071. 
      Epub 2011 Apr 1.