PMID- 21458335
OWN - NLM
STAT- MEDLINE
DCOM- 20120329
LR  - 20200306
IS  - 1532-2971 (Electronic)
IS  - 1090-0233 (Linking)
VI  - 190
IP  - 2
DP  - 2011 Nov
TI  - Commercial spray-dried porcine plasma does not transmit porcine circovirus type 2 
      in weaned pigs challenged with porcine reproductive and respiratory syndrome 
      virus.
PG  - e16-e20
LID - S1090-0233(11)00082-7 [pii]
LID - 10.1016/j.tvjl.2011.02.021 [doi]
AB  - The objective of this study was to evaluate if spray dried porcine plasma (SDPP) 
      containing porcine circovirus type 2 (PCV2) genome supplemented in feed could 
      transmit PCV2 to pigs challenged with porcine reproductive and respiratory 
      syndrome virus (PRRSV). Twenty-three PRRSV-free pigs, non-viraemic for PCV2, were 
      housed in bio-safety level 3 facilities and assigned to four groups in a 2x2 
      factorial design consisting of PRRSV challenge and a negative control. The diet 
      contained 0 or 8kg SDPP per 100kg of feed. PRRSV challenge groups were inoculated 
      intranasally with 2mL of a suspension containing 10(6) TCID(50)/mL PRRSV. The 
      SDPP used in the study contained 7.56x10(5) PCV2 genome copies per gram. Dietary 
      treatments were fed from 4days prior to PRRSV inoculation until 28days 
      post-inoculation (PI). All challenged pigs developed PRRSV viraemia by day 3PI 
      and PRRSV antibodies were detected in sera by day 14PI, with no difference 
      between diet treatments. Neither PRRSV viraemia nor seroconversion was observed 
      in non-challenged pigs. PCV2 was not detected in the serum of any pigs throughout 
      the experimental period. SDPP containing the PCV2 genome supplemented in feed did 
      not result in PCV2 transmission to either healthy or PRRSV-infected pigs under 
      these experimental conditions.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Pujols, Joan
AU  - Pujols J
AD  - Institut de Recerca i Tecnologia Agroalimentaries (IRTA), Barcelona, Spain; 
      Centre de Recerca en Sanitat Animal (CReSA), Fundacion UAB-IRTA, Campus de la 
      Universitat Autonoma de Barcelona, 08193 Barcelona, Spain.
FAU - Lorca-Oro, Cristina
AU  - Lorca-Oro C
AD  - Centre de Recerca en Sanitat Animal (CReSA), Fundacion UAB-IRTA, Campus de la 
      Universitat Autonoma de Barcelona, 08193 Barcelona, Spain.
FAU - Diaz, Ivan
AU  - Diaz I
AD  - Centre de Recerca en Sanitat Animal (CReSA), Fundacion UAB-IRTA, Campus de la 
      Universitat Autonoma de Barcelona, 08193 Barcelona, Spain.
FAU - Russell, Louis E
AU  - Russell LE
AD  - APC Inc., Ankeny, IA 50021, USA.
FAU - Campbell, Joy M
AU  - Campbell JM
AD  - APC Inc., Ankeny, IA 50021, USA.
FAU - Crenshaw, Joe D
AU  - Crenshaw JD
AD  - APC Inc., Ankeny, IA 50021, USA.
FAU - Polo, Javier
AU  - Polo J
AD  - APC Europe, S.A., 08403 Granollers, Spain. Electronic address: 
      javier.polo@ampc-europe.com.
FAU - Mateu, Enric
AU  - Mateu E
AD  - Centre de Recerca en Sanitat Animal (CReSA), Fundacion UAB-IRTA, Campus de la 
      Universitat Autonoma de Barcelona, 08193 Barcelona, Spain; Departament de Sanitat 
      i Anatomia Animals, Facultat de Veterinaria, Universitat Autonoma de Barcelona 
      (UAB), 08193 Barcelona, Spain.
FAU - Segales, Joaquim
AU  - Segales J
AD  - Centre de Recerca en Sanitat Animal (CReSA), Fundacion UAB-IRTA, Campus de la 
      Universitat Autonoma de Barcelona, 08193 Barcelona, Spain; Departament de Sanitat 
      i Anatomia Animals, Facultat de Veterinaria, Universitat Autonoma de Barcelona 
      (UAB), 08193 Barcelona, Spain.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20110331
PL  - England
TA  - Vet J
JT  - Veterinary journal (London, England : 1997)
JID - 9706281
SB  - IM
MH  - Analysis of Variance
MH  - Animal Feed/*virology
MH  - Animals
MH  - Circovirus/genetics
MH  - Genome, Viral
MH  - Immunocompromised Host
MH  - Linear Models
MH  - Plasma/*virology
MH  - Porcine Postweaning Multisystemic Wasting Syndrome/immunology/*transmission
MH  - Porcine Reproductive and Respiratory Syndrome/*immunology
MH  - Swine
EDAT- 2011/04/05 06:00
MHDA- 2012/03/30 06:00
CRDT- 2011/04/05 06:00
PHST- 2010/09/20 00:00 [received]
PHST- 2011/02/13 00:00 [revised]
PHST- 2011/02/23 00:00 [accepted]
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2012/03/30 06:00 [medline]
AID - S1090-0233(11)00082-7 [pii]
AID - 10.1016/j.tvjl.2011.02.021 [doi]
PST - ppublish
SO  - Vet J. 2011 Nov;190(2):e16-e20. doi: 10.1016/j.tvjl.2011.02.021. Epub 2011 Mar 
      31.