PMID- 21458623
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20211020
IS  - 1097-6868 (Electronic)
IS  - 0002-9378 (Print)
IS  - 0002-9378 (Linking)
VI  - 204
IP  - 4
DP  - 2011 Apr
TI  - Endothelin type A receptor antagonist attenuates placental ischemia-induced 
      hypertension and uterine vascular resistance.
PG  - 330.e1-4
LID - 10.1016/j.ajog.2011.01.049 [doi]
AB  - OBJECTIVE: We sought to determine the effect of an endothelin type A receptor 
      antagonist (ETA) on uterine artery resistive index (UARI) and mean arterial 
      pressure (MAP) in a placental ischemia rat model of preeclampsia produced by 
      reduction in uterine perfusion pressure (RUPP). STUDY DESIGN: UARI was assessed 
      by Doppler velocimetry in RUPP and normal pregnant controls (NP) on gestational 
      days (GD) 12, 15, and 18. UARI was also determined on GD 18 in NP and RUPP 
      pregnant dams after pretreatment with ETA. MAP was recorded on GD 19. RESULTS: 
      The RUPP group had a higher MAP and UARI on GD 15 and 18 than the NP group. 
      Pretreatment with ETA attenuated both the MAP and GD-18 UARI in the RUPP group 
      without affecting these parameters in the NP group. CONCLUSION: The improvement 
      in UARI could be one potential mechanism for the reduction in MAP in response to 
      ETA in pregnant dams with ischemic placentas.
CI  - Copyright (c) 2011 Mosby, Inc. All rights reserved.
FAU - Tam Tam, Kiran B
AU  - Tam Tam KB
AD  - Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, 
      University of Mississippi Medical Center, Jackson, MS 39216, USA.
FAU - George, Eric
AU  - George E
FAU - Cockrell, Kathy
AU  - Cockrell K
FAU - Arany, Marietta
AU  - Arany M
FAU - Speed, Joshua
AU  - Speed J
FAU - Martin, James N Jr
AU  - Martin JN Jr
FAU - Lamarca, Babbette
AU  - Lamarca B
FAU - Granger, Joey P
AU  - Granger JP
LA  - eng
GR  - P01 HL051971/HL/NHLBI NIH HHS/United States
GR  - P01 HL051971-16/HL/NHLBI NIH HHS/United States
GR  - HL-51971/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Am J Obstet Gynecol
JT  - American journal of obstetrics and gynecology
JID - 0370476
RN  - 0 (Endothelin Receptor Antagonists)
RN  - 0 (Pyrrolidines)
RN  - V6D7VK2215 (Atrasentan)
SB  - IM
MH  - Animals
MH  - Atrasentan
MH  - Blood Flow Velocity/drug effects/physiology
MH  - Blood Pressure/drug effects/physiology
MH  - Disease Models, Animal
MH  - *Endothelin Receptor Antagonists
MH  - Female
MH  - Hypertension/*drug therapy/physiopathology
MH  - Ischemia/drug therapy/physiopathology
MH  - Placenta/*blood supply/drug effects/physiopathology
MH  - Pregnancy
MH  - Pyrrolidines/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Ultrasonography
MH  - Uterine Artery/diagnostic imaging/*physiopathology
MH  - Vascular Resistance/*drug effects/physiology
PMC - PMC3072697
MID - NIHMS280580
EDAT- 2011/04/05 06:00
MHDA- 2011/06/29 06:00
PMCR- 2012/04/01
CRDT- 2011/04/05 06:00
PHST- 2010/11/23 00:00 [received]
PHST- 2011/01/19 00:00 [revised]
PHST- 2011/01/24 00:00 [accepted]
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
PHST- 2012/04/01 00:00 [pmc-release]
AID - S0002-9378(11)00142-6 [pii]
AID - 10.1016/j.ajog.2011.01.049 [doi]
PST - ppublish
SO  - Am J Obstet Gynecol. 2011 Apr;204(4):330.e1-4. doi: 10.1016/j.ajog.2011.01.049.