PMID- 21459816
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20211020
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 203
IP  - 9
DP  - 2011 May 1
TI  - Human leukocyte antigen class I region single-nucleotide polymorphisms are 
      associated with leprosy susceptibility in Vietnam and India.
PG  - 1274-81
LID - 10.1093/infdis/jir024 [doi]
AB  - Experimental evidence suggested the existence of unidentified leprosy 
      susceptibility loci in the human leukocyte antigen (HLA) complex. To identify 
      such genetic risk factors, a high-density association scan of a 1.9-mega-base 
      (Mb) region in the HLA complex was performed. Among 682 single-nucleotide 
      polymorphisms (SNPs), 59 were associated with leprosy (P <.01) in 198 Vietnamese 
      single-case leprosy families. Genotyping of these SNPs in an independent sample 
      of 292 Vietnamese single-case leprosy families replicated the association of 12 
      SNPs (P <.01). Multivariate analysis of these 12 SNPs showed that the association 
      information could be captured by 2 intergenic HLA class I region SNPs (P = 9.4 x 
      10(-)(9))-rs2394885 and rs2922997 (marginal multivariate P = 2.1 x 10(-)(7) and P = 
      .0016, respectively). SNP rs2394885 tagged the HLA-C*15:05 allele in the 
      Vietnamese population. The identical associations were validated in a third 
      sample of 364 patients with leprosy and 371 control subjects from North India. 
      These results implicated class I alleles in leprosy pathogenesis.
FAU - Alter, Andrea
AU  - Alter A
AD  - Research Institute of the McGill University Health Centre, McGill Centre for the 
      Study of Host Resistance, Departments of Medicine and Human Genetics, McGill 
      University, Montreal, Quebec, Canada.
FAU - Huong, Nguyen Thu
AU  - Huong NT
FAU - Singh, Meenakshi
AU  - Singh M
FAU - Orlova, Marianna
AU  - Orlova M
FAU - Van Thuc, Nguyen
AU  - Van Thuc N
FAU - Katoch, Kiran
AU  - Katoch K
FAU - Gao, Xiaojiang
AU  - Gao X
FAU - Thai, Vu Hong
AU  - Thai VH
FAU - Ba, Nguyen Ngoc
AU  - Ba NN
FAU - Carrington, Mary
AU  - Carrington M
FAU - Abel, Laurent
AU  - Abel L
FAU - Mehra, Narinder
AU  - Mehra N
FAU - Alcais, Alexandre
AU  - Alcais A
FAU - Schurr, Erwin
AU  - Schurr E
LA  - eng
GR  - P30 AI060354/AI/NIAID NIH HHS/United States
GR  - 5UL1RR024143-03/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Child, Preschool
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - India
MH  - Infant
MH  - Leprosy/*genetics/immunology
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Vietnam
MH  - Young Adult
PMC - PMC3069725
EDAT- 2011/04/05 06:00
MHDA- 2011/06/01 06:00
PMCR- 2012/05/01
CRDT- 2011/04/05 06:00
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
PHST- 2012/05/01 00:00 [pmc-release]
AID - jir024 [pii]
AID - 10.1093/infdis/jir024 [doi]
PST - ppublish
SO  - J Infect Dis. 2011 May 1;203(9):1274-81. doi: 10.1093/infdis/jir024.