PMID- 21460029
OWN - NLM
STAT- MEDLINE
DCOM- 20110902
LR  - 20110623
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 260
IP  - 1
DP  - 2011 Jul
TI  - Corrected tetralogy of Fallot: comparison of tissue doppler imaging and 
      velocity-encoded MR for assessment of performance and temporal activation of 
      right ventricle.
PG  - 88-97
LID - 10.1148/radiol.11101993 [doi]
AB  - PURPOSE: To compare velocity-encoded (VE) magnetic resonance (MR) imaging with 
      tissue Doppler imaging to assess right ventricular (RV) peak systolic velocities 
      and timing of velocities in patients with corrected tetralogy of Fallot and 
      healthy subjects. MATERIALS AND METHODS: Local institutional review board 
      approval was obtained; patients or their parents gave informed consent. 
      Thirty-three patients (20 male, 13 female; median age, 12 years; interquartile 
      range [IQR], 11-15 years; age range, 8-18 years) and 19 control subjects (12 
      male, seven female; median age, 14 years; IQR, 12-16 years; age range, 8-18 
      years) underwent VE MR imaging and tissue Doppler imaging. Peak systolic velocity 
      and time to peak systolic velocity (percentage of cardiac cycle) were assessed at 
      the RV free wall (RVFW) and RV outflow tract (RVOT). Data were analyzed by using 
      linear regression, paired and unpaired tests, and Bland-Altman plots. RESULTS: 
      Good correlation and agreement between the two techniques were observed. For peak 
      systolic velocity at RVFW, r = 0.95 (mean difference, -0.4 cm/sec, P < .01), and 
      at RVOT, r = 0.95 (mean difference, -0.4 cm/sec, P = .02). For timing at RVFW, r 
      = 0.94 (mean difference, -0.2%, P = .44), and at RVOT, r = 0.89 (mean difference, 
      -0.5%, P = .01). Peak systolic velocity was reduced in patients with corrected 
      tetralogy of Fallot (at RVFW, median was 8.2 cm/sec [IQR, 6.4-9.7 cm/sec] vs 12.4 
      cm/sec [IQR, 10.8-13.8 cm/sec], P < .01; at RVOT, 4.7 cm/sec [IQR, 4.1-7.2 
      cm/sec] vs 10.2 cm/sec [IQR, 8.7-11.2 cm/sec], P < .01). The time delay between 
      RVFW and RVOT was observed, which was significantly shorter in patients with 
      corrected tetralogy of Fallot (median, 5.9% [IQR, 4.9%-7.4%] vs 8.4% [IQR, 
      6.6%-12.4%], P < .01). CONCLUSION: VE MR imaging and tissue Doppler imaging 
      enable assessment of RV systolic performance and timing of velocities at the RVFW 
      and RVOT in patients with corrected tetralogy of Fallot. Both techniques can be 
      used interchangeably to clinically assess velocities and timing of velocities of 
      the RV.
FAU - van der Hulst, Annelies E
AU  - van der Hulst AE
AD  - Division of Pediatric Cardiology, Department of Pediatrics J6-S, Leiden 
      University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The 
      Netherlands. a.e.van_der_hulst@lumc.nl
FAU - Roest, Arno A W
AU  - Roest AA
FAU - Delgado, Victoria
AU  - Delgado V
FAU - Kroft, Lucia J M
AU  - Kroft LJ
FAU - Holman, Eduard R
AU  - Holman ER
FAU - Blom, Nico A
AU  - Blom NA
FAU - Bax, Jeroen J
AU  - Bax JJ
FAU - de Roos, Albert
AU  - de Roos A
FAU - Westenberg, Jos J M
AU  - Westenberg JJ
LA  - eng
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110401
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Elasticity Imaging Techniques/*methods
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Tetralogy of Fallot/complications/*diagnosis/*surgery
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Right/*diagnosis/etiology/*surgery
EDAT- 2011/04/05 06:00
MHDA- 2011/09/03 06:00
CRDT- 2011/04/05 06:00
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2011/09/03 06:00 [medline]
AID - radiol.11101993 [pii]
AID - 10.1148/radiol.11101993 [doi]
PST - ppublish
SO  - Radiology. 2011 Jul;260(1):88-97. doi: 10.1148/radiol.11101993. Epub 2011 Apr 1.