PMID- 21460793
OWN - NLM
STAT- MEDLINE
DCOM- 20110822
LR  - 20211020
IS  - 1469-3178 (Electronic)
IS  - 1469-221X (Print)
IS  - 1469-221X (Linking)
VI  - 12
IP  - 5
DP  - 2011 May
TI  - APOBEC3A can activate the DNA damage response and cause cell-cycle arrest.
PG  - 444-50
LID - 10.1038/embor.2011.46 [doi]
AB  - Human apolipoprotein-B mRNA-editing catalytic polypeptide-like 3 (APOBEC3) 
      proteins constitute a family of cytidine deaminases that mediate restriction of 
      retroviruses, endogenous retro-elements and DNA viruses. It is well established 
      that these enzymes are potent mutators of viral DNA, but it is unclear whether 
      their editing activity is a threat to the integrity of the cellular genome. We 
      show that expression of APOBEC3A can lead to induction of DNA breaks and 
      activation of damage responses in a deaminase-dependent manner. Consistent with 
      these observations, APOBEC3A expression induces cell-cycle arrest. These results 
      indicate that cellular DNA is vulnerable to APOBEC3 activity and deregulated 
      expression of APOBEC3A could threaten genomic integrity.
FAU - Landry, Sebastien
AU  - Landry S
AD  - Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North 
      Torrey Pines Road, La Jolla, California 92037, USA.
FAU - Narvaiza, Inigo
AU  - Narvaiza I
FAU - Linfesty, Daniel C
AU  - Linfesty DC
FAU - Weitzman, Matthew D
AU  - Weitzman MD
LA  - eng
GR  - R01 AI067952/AI/NIAID NIH HHS/United States
GR  - R01 AI074967/AI/NIAID NIH HHS/United States
GR  - AI067952/AI/NIAID NIH HHS/United States
GR  - AI074967/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110401
PL  - England
TA  - EMBO Rep
JT  - EMBO reports
JID - 100963049
RN  - 0 (H2AX protein, human)
RN  - 0 (Histones)
RN  - 0 (Proteins)
RN  - EC 3.2.2.- (Uracil-DNA Glycosidase)
RN  - EC 3.5.4.- (Nucleotide Deaminases)
RN  - EC 3.5.4.5 (APOBEC3A protein, human)
RN  - EC 3.5.4.5 (Cytidine Deaminase)
RN  - G34N38R2N1 (Bromodeoxyuridine)
SB  - IM
MH  - Blotting, Western
MH  - Bromodeoxyuridine
MH  - Cell Cycle/*physiology
MH  - Cell Line
MH  - Cytidine Deaminase/*metabolism
MH  - DNA Damage/*genetics
MH  - Fluorescent Antibody Technique
MH  - Histones/metabolism
MH  - Humans
MH  - In Situ Nick-End Labeling
MH  - Nucleotide Deaminases/metabolism
MH  - Phosphorylation
MH  - Proteins/*metabolism
MH  - Uracil-DNA Glycosidase/metabolism
PMC - PMC3090015
COIS- The authors declare that they have no conflict of interest.
EDAT- 2011/04/05 06:00
MHDA- 2011/08/23 06:00
PMCR- 2012/05/01
CRDT- 2011/04/05 06:00
PHST- 2010/09/28 00:00 [received]
PHST- 2011/02/04 00:00 [revised]
PHST- 2011/02/24 00:00 [accepted]
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2011/08/23 06:00 [medline]
PHST- 2012/05/01 00:00 [pmc-release]
AID - embor201146 [pii]
AID - 10.1038/embor.2011.46 [doi]
PST - ppublish
SO  - EMBO Rep. 2011 May;12(5):444-50. doi: 10.1038/embor.2011.46. Epub 2011 Apr 1.