PMID- 21463182 OWN - NLM STAT- MEDLINE DCOM- 20111220 LR - 20131121 IS - 1651-2006 (Electronic) IS - 1401-7431 (Linking) VI - 45 IP - 4 DP - 2011 Aug TI - Coronary microembolization causes long-term detrimental effects on regional left ventricular function. PG - 205-14 LID - 10.3109/14017431.2011.568629 [doi] AB - OBJECTIVES: To investigate whether coronary microemboli have long-term effects on left ventricular (LV) function in an experimental model. Furthermore, to determine if first-pass perfusion and late gadolinium enhancement (LGE) patterns differs between small- and large-sized microemboli. DESIGN: Six pigs underwent left anterior descending (LAD)-coronary microembolization with small-sized (40-120 mum, n approximately 250 000) microemboli using a combined x-ray and MRI-system. MR-images before, one hour after and 7-8 weeks after microembolization were obtained. Results were compared to MRI obtained by large-sized (100-300 mum, n approximately 7200) microemboli. RESULTS: Cine MRI showed an acute drop in ejection fraction (from 49.5 +/- 2.6% to 32.5 +/- 2.8) that substantially recovered at 7-8 weeks (47.5 +/- 3.2%). Regional LV-function assessed as circumferential, longitudinal and radial strain declined in both microinfarcts and remote regions followed by partial recovery at 7-8 weeks. The decline in LV function and the severe perfusion deficit from the small microemboli was similar to the large microemboli at one hour. There was a significant recovery in perfusion at 7-8 weeks in the microinfarcts. LGE demonstrated the microinfarcts at 7-8 weeks but not at one hour and the microinfarcts were confirmed by histopathology. CONCLUSION: Microembolization causes long-term, regional LV dysfunction and this study confirmed the need of a comprehensive MRI-protocol for the detection of microinfarcts. These findings suggest that even small microemboli (40-120 mum in diameter), which may escape the distal protective devices influence cardiac function. FAU - Carlsson, Marcus AU - Carlsson M AD - Department of Clinical Physiology, Lund University, Skane University Hospital, Lund, Sweden. Marcus.carlsson@med.lu.se FAU - Jablonowski, Robert AU - Jablonowski R FAU - Martin, Alastair J AU - Martin AJ FAU - Ursell, Philip C AU - Ursell PC FAU - Saeed, Maythem AU - Saeed M LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20110404 PL - England TA - Scand Cardiovasc J JT - Scandinavian cardiovascular journal : SCJ JID - 9708377 RN - K2I13DR72L (Gadolinium DTPA) SB - IM MH - Animals MH - *Coronary Vessels MH - Embolism/*complications/physiopathology MH - Gadolinium DTPA MH - Image Enhancement MH - Longitudinal Studies MH - Magnetic Resonance Imaging/methods MH - Microspheres MH - Myocardial Infarction/*physiopathology MH - Myocardial Perfusion Imaging MH - Swine MH - Ventricular Dysfunction, Left/*etiology/physiopathology EDAT- 2011/04/06 06:00 MHDA- 2011/12/21 06:00 CRDT- 2011/04/06 06:00 PHST- 2011/04/06 06:00 [entrez] PHST- 2011/04/06 06:00 [pubmed] PHST- 2011/12/21 06:00 [medline] AID - 10.3109/14017431.2011.568629 [doi] PST - ppublish SO - Scand Cardiovasc J. 2011 Aug;45(4):205-14. doi: 10.3109/14017431.2011.568629. Epub 2011 Apr 4.