PMID- 21464751
OWN - NLM
STAT- MEDLINE
DCOM- 20111202
LR  - 20110420
IS  - 1536-4801 (Electronic)
IS  - 0277-2116 (Linking)
VI  - 52
IP  - 5
DP  - 2011 May
TI  - Association of polymorphisms in the Interleukin-18 gene with susceptibility to 
      biliary atresia.
PG  - 607-11
LID - 10.1097/MPG.0b013e3182111b9b [doi]
AB  - BACKGROUND AND OBJECTIVE: Biliary atresia (BA) is a destructive inflammatory 
      obliterative cholangiopathy of neonates that affects both intrahepatic and 
      extrahepatic bile ducts. Although the etiology is unknown, immunologically 
      mediated injury of the bile ducts triggered by as yet unidentified infectious 
      agents is likely to play a critical role. Interleukin-18 (IL-18) is a 
      proinflammatory cytokine that plays an important role in immune, infectious, and 
      inflammatory diseases because of its induction of interferon-gamma. In this 
      study, we investigated whether polymorphisms of the IL18 gene were associated 
      with susceptibility to BA. PATIENTS AND METHODS: Genomic DNA was extracted from 
      whole-blood samples of 50 Taiwanese children with BA and 1117 ethnically matched 
      healthy controls. The IL18 -1297 T/C, -607 C/A, -137 G/C, and +105 A/C 
      polymorphisms were genotyped using the TaqMan assay. RESULTS: No statistically 
      significant differences of genotype, allele, carrier, and haplotype frequencies 
      of these IL18 gene variants were found between children with BA and healthy 
      controls. CONCLUSIONS: Our data suggest that the IL18 gene does not play a major 
      role in BA predisposition in Taiwanese children.
FAU - Lee, Hung-Chang
AU  - Lee HC
AD  - Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.
FAU - Chang, Tzu-Yang
AU  - Chang TY
FAU - Yeung, Chun-Yan
AU  - Yeung CY
FAU - Chan, Wai-Tao
AU  - Chan WT
FAU - Jiang, Chuen-Bin
AU  - Jiang CB
FAU - Chan, Hui-Wen
AU  - Chan HW
FAU - Chen, Wei-Fang
AU  - Chen WF
FAU - Yang, Horng-Woei
AU  - Yang HW
FAU - Lin, Marie
AU  - Lin M
FAU - Lee, Yann-Jinn
AU  - Lee YJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pediatr Gastroenterol Nutr
JT  - Journal of pediatric gastroenterology and nutrition
JID - 8211545
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Biliary Atresia/*genetics
MH  - Case-Control Studies
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Interleukin-18/*genetics
MH  - *Polymorphism, Genetic
MH  - Taiwan
EDAT- 2011/04/06 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/04/06 06:00
PHST- 2011/04/06 06:00 [entrez]
PHST- 2011/04/06 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1097/MPG.0b013e3182111b9b [doi]
PST - ppublish
SO  - J Pediatr Gastroenterol Nutr. 2011 May;52(5):607-11. doi: 
      10.1097/MPG.0b013e3182111b9b.