PMID- 2146511
OWN - NLM
STAT- MEDLINE
DCOM- 19901227
LR  - 20051117
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 348
IP  - 6298
DP  - 1990 Nov 15
TI  - Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-I pX in patients with 
      HTLV-I associated neurological disease.
PG  - 245-8
AB  - The human T-lymphotropic virus type I (HTLV-I), the first human retrovirus to be 
      characterized, is associated with adult T-cell leukaemia and a chronic 
      progressive disease of the central nervous system termed tropical spastic 
      paraparesis, or HTLV-I-associated myelopathy. Only 1% of individuals infected 
      with HTLV-I develop clinical disease however. The various manifestations of an 
      HTLV-I infection may be related to differences in the genetic backgrounds of 
      individuals, infection with variant strains of HTLV-I, differences in viral 
      tropism or host immune response to the virus. Whereas the humoral response to 
      HTLV-I is well characterized, little is known about the human cellular immune 
      response, such as the production of cytotoxic T lymphocytes. Here we report the 
      presence of high levels of circulating HTLV-I-specific cytotoxic T lymphocytes in 
      patients with HTLV-I associated neurological disease but not in HTLV-I 
      seropositive individuals without neurological involvement. These cytotoxic T 
      lymphocytes are CD8+, HLA class I- restricted and predominantly recognize the 
      HTLV-I gene products encoded in the regulatory region pX. These findings suggest 
      that HTLV-I-specific cytotoxic T lymphocytes may contribute to the pathogenesis 
      of associated neurological disorders associated with HTLV-I.
FAU - Jacobson, S
AU  - Jacobson S
AD  - Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, 
      National Institutes of Health, Bethesda, Maryland 20892.
FAU - Shida, H
AU  - Shida H
FAU - McFarlin, D E
AU  - McFarlin DE
FAU - Fauci, A S
AU  - Fauci AS
FAU - Koenig, S
AU  - Koenig S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (DNA, Recombinant)
RN  - 0 (Gene Products, env)
RN  - 0 (Gene Products, rex)
RN  - 0 (Gene Products, tax)
SB  - IM
MH  - Adult
MH  - Cell Line, Transformed
MH  - DNA, Recombinant
MH  - Female
MH  - Gene Expression
MH  - Gene Products, env/genetics/immunology
MH  - Gene Products, rex/genetics/immunology
MH  - Gene Products, tax/genetics/immunology
MH  - HTLV-I Infections/immunology
MH  - Human T-lymphotropic virus 1/genetics/*immunology
MH  - Humans
MH  - Leukemia, T-Cell/immunology
MH  - Male
MH  - Middle Aged
MH  - Paraparesis, Tropical Spastic/*immunology
MH  - T-Lymphocytes, Cytotoxic/*immunology
MH  - T-Lymphocytes, Regulatory/*immunology
MH  - Transfection
MH  - Vaccinia virus/genetics
EDAT- 1990/11/15 00:00
MHDA- 1990/11/15 00:01
CRDT- 1990/11/15 00:00
PHST- 1990/11/15 00:00 [pubmed]
PHST- 1990/11/15 00:01 [medline]
PHST- 1990/11/15 00:00 [entrez]
AID - 10.1038/348245a0 [doi]
PST - ppublish
SO  - Nature. 1990 Nov 15;348(6298):245-8. doi: 10.1038/348245a0.