PMID- 21466263
OWN - NLM
STAT- MEDLINE
DCOM- 20111206
LR  - 20151119
IS  - 1651-2251 (Electronic)
IS  - 0001-6489 (Linking)
VI  - 131
IP  - 7
DP  - 2011 Jul
TI  - Prognostic significance of matrix metalloproteinase-20 overexpression in 
      laryngeal squamous cell carcinoma.
PG  - 769-73
LID - 10.3109/00016489.2011.560186 [doi]
AB  - CONCLUSION: Matrix metalloproteinase (MMP)-20 is overexpressed in laryngeal 
      squamous cell carcinoma (LSCC) compared with the adjacent normal laryngeal 
      epithelium and MMP-20 plays a role in lymph node metastasis. Overexpression of 
      MMP-20 may be used as a significant prognostic factor for lymph node metastasis. 
      All the findings indicate that MMP-20 may play a role in the initiation and 
      progression of LSCC. OBJECTIVE: The MMPs are a gene family of zinc-dependent 
      endopeptidases that have been implicated in tumor invasion and metastasis, and 
      MMP-20 is a new member of the MMP family. The purpose of this study was to 
      investigate whether MMP-20 is overexpressed in human LSCC and, if so, the 
      significance of its overexpression in relation to clinical parameters. METHODS: 
      We analyzed 33 cases of LSCC with RT-PCR and 73 cases of LSCC with 
      immunohistochemistry compared with normal laryngeal epithelium. RESULTS: We found 
      that MMP-20 is overexpresssed in LSCC compared with the adjacent normal laryngeal 
      epithelium.
FAU - Liu, Yehai
AU  - Liu Y
AD  - Department of Otolaryngology, Head and Neck Surgery, First Affiliated Hospital of 
      Anhui Medical University, Hefei, Anhui Province, China.
FAU - Li, Yifan
AU  - Li Y
FAU - Liu, Zhongmin
AU  - Liu Z
FAU - Zhang, Liyong
AU  - Zhang L
FAU - Anniko, Matti
AU  - Anniko M
FAU - Duan, Maoli
AU  - Duan M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110405
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (RNA, Neoplasm)
RN  - EC 3.4.24.- (Matrix Metalloproteinase 20)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/biosynthesis/genetics
MH  - Carcinoma, Squamous Cell/enzymology/*genetics/secondary
MH  - Disease Progression
MH  - Female
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/enzymology/*genetics/pathology
MH  - Lymphatic Metastasis/genetics
MH  - Male
MH  - Matrix Metalloproteinase 20/biosynthesis/*genetics
MH  - Middle Aged
MH  - Prognosis
MH  - RNA, Neoplasm/*genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2011/04/07 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/04/07 06:00
PHST- 2011/04/07 06:00 [entrez]
PHST- 2011/04/07 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.3109/00016489.2011.560186 [doi]
PST - ppublish
SO  - Acta Otolaryngol. 2011 Jul;131(7):769-73. doi: 10.3109/00016489.2011.560186. Epub 
      2011 Apr 5.