PMID- 21466746
OWN - NLM
STAT- MEDLINE
DCOM- 20120730
LR  - 20161020
IS  - 1469-5111 (Electronic)
IS  - 1461-1457 (Linking)
VI  - 14
IP  - 10
DP  - 2011 Nov
TI  - Study on the possible association of brain-derived neurotrophic factor 
      polymorphism with the developmental course of symptoms of attention deficit and 
      hyperactivity.
PG  - 1367-76
LID - 10.1017/S1461145711000502 [doi]
AB  - Several studies have, with conflicting results, investigated the relationship 
      between the Val(6)(6)Met polymorphism in brain-derived neurotrophic factor (BDNF) and 
      attention deficit hyperactivity disorder (ADHD). We assessed longitudinal, 
      quantitative phenotypes of hyperactivity-impulsivity and inattention in order to 
      determine whether the Val(6)(6)Met polymorphism is associated with age-specific 
      and/or persistent symptoms of hyperactivity-impulsivity and/or inattention in a 
      community-based cohort of 1236 Swedish individuals for which ADHD symptom data 
      were collected when the participants were aged 8-9, 13-14 and 16-17 yr. The Met 
      allele was associated with symptoms of ADHD at ages 8-9 and 13-14 yr. A 
      multivariate regression analysis revealed that the observed effect of the Met 
      allele on ADHD symptoms reflects an influence on persistent 
      hyperactivity-impulsivity symptoms. The present findings support the hypothesis 
      that BDNF is involved in the pathogenesis of ADHD. The results highlight the 
      importance of distinguishing between hyperactivity-impulsivity and inattention, 
      respectively, and demonstrate the value of using a longitudinal approach in 
      genetic studies of ADHD symptoms.
FAU - Bergman, Olle
AU  - Bergman O
AD  - Department of Pharmacology, University of Gothenburg, Gothenburg, Sweden. 
      olle.bergman@pharm.gu.se
FAU - Westberg, Lars
AU  - Westberg L
FAU - Lichtenstein, Paul
AU  - Lichtenstein P
FAU - Eriksson, Elias
AU  - Eriksson E
FAU - Larsson, Henrik
AU  - Larsson H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Twin Study
DEP - 20110405
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - *Adolescent Behavior
MH  - Age Factors
MH  - Attention
MH  - Attention Deficit Disorder with Hyperactivity/diagnosis/*genetics/psychology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Child
MH  - *Child Behavior
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Impulsive Behavior/genetics
MH  - Logistic Models
MH  - Longitudinal Studies
MH  - Male
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Phenotype
MH  - *Polymorphism, Single Nucleotide
MH  - Risk Assessment
MH  - Risk Factors
MH  - Surveys and Questionnaires
MH  - Sweden
MH  - Young Adult
EDAT- 2011/04/07 06:00
MHDA- 2012/07/31 06:00
CRDT- 2011/04/07 06:00
PHST- 2011/04/07 06:00 [entrez]
PHST- 2011/04/07 06:00 [pubmed]
PHST- 2012/07/31 06:00 [medline]
AID - S1461145711000502 [pii]
AID - 10.1017/S1461145711000502 [doi]
PST - ppublish
SO  - Int J Neuropsychopharmacol. 2011 Nov;14(10):1367-76. doi: 
      10.1017/S1461145711000502. Epub 2011 Apr 5.