PMID- 21466778
OWN - NLM
STAT- MEDLINE
DCOM- 20121211
LR  - 20131121
IS  - 0040-5957 (Print)
IS  - 0040-5957 (Linking)
VI  - 66
IP  - 1
DP  - 2011 Jan-Feb
TI  - [Level of evidence for therapeutic drug monitoring of MPA in hematopoietic stem 
      cell transplantation].
PG  - 51-5
AB  - Mycophenolic acid (MPA) is more and more used to prevent GVHD (Graft Versus Host 
      Disease) during hematopoietic stem cell transplantation with reduce-intensity 
      conditioning. If several facts argue in favor of therapeutic drug monitoring, the 
      used pharmacokinetic parameter is to be defined. Especially, the choice between 
      total or ultrafilterable MPA is still under debate even if therapeutic drug 
      monitoring seems to be more practicable with total MPA. The role of other factors 
      implied in GVHD occurrence are also to be assessed in studies which aim at 
      assessing therapeutic drug monitoring of MPA in such situation. For theses 
      reasons, the level evidence of MPA as GVHD prophylaxis during hematopoietic stem 
      cell transplantation with reduce-intensity conditioning is potentially useful.
CI  - (c) 2011 Societe Francaise de Pharmacologie et de Therapeutique.
FAU - Gerritsen-van Schieveen, Pauline
AU  - Gerritsen-van Schieveen P
AD  - CHU Besancon, Laboratoire de Pharmacologie Clinique, Hopital Jean Minjoz, 
      Besancon, France.
FAU - Royer, Bernard
AU  - Royer B
CN  - Groupe Suivi Therapeutique Pharmacologique de la Societe Francaise de 
      Pharmacologie et de Therapeutique
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Niveau de preuve du suivi therapeutique pharmacologique de l'acide mycophenolique 
      administre pour la prevention des reactions du greffon contre l'hote au cours des 
      greffes de cellules souches avec un conditionnement reduit.
DEP - 20110407
PL  - France
TA  - Therapie
JT  - Therapie
JID - 0420544
RN  - HU9DX48N0T (Mycophenolic Acid)
SB  - IM
MH  - Drug Monitoring/*methods
MH  - Evidence-Based Medicine
MH  - Graft vs Host Disease/immunology/*prevention & control
MH  - Hematopoietic Stem Cell Transplantation/*methods
MH  - Humans
MH  - Mycophenolic Acid/adverse effects/pharmacokinetics/*therapeutic use
EDAT- 2011/04/07 06:00
MHDA- 2012/12/12 06:00
CRDT- 2011/04/07 06:00
PHST- 2010/01/05 00:00 [received]
PHST- 2010/11/30 00:00 [accepted]
PHST- 2011/04/07 06:00 [entrez]
PHST- 2011/04/07 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - th101851 [pii]
AID - 10.2515/therapie/2010024 [doi]
PST - ppublish
SO  - Therapie. 2011 Jan-Feb;66(1):51-5. doi: 10.2515/therapie/2010024. Epub 2011 Apr 
      7.