PMID- 21467133
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20110505
IS  - 1940-6215 (Electronic)
IS  - 1940-6215 (Linking)
VI  - 4
IP  - 5
DP  - 2011 May
TI  - Effects of maternal exposure to cow's milk high or low in isoflavones on 
      carcinogen-induced mammary tumorigenesis among rat offspring.
PG  - 694-701
LID - 10.1158/1940-6207.CAPR-10-0220 [doi]
AB  - We investigated whether maternal exposure during pregnancy to cow's milk 
      containing endogenous estrogens and insulin-like growth factor 1 (IGF-1) and 
      either high or low levels of isoflavones from dietary legumes (HIM and LIM, 
      respectively) affected carcinogen-induced mammary carcinogenesis in female rat 
      offspring. Pregnant Sprague-Dawley rats were given HIM, LIM, or tap water 
      (control) from gestational day (GD) 11 until birth; hereafter all rats received 
      tap water. Mammary tumorigenesis was induced by administrating 
      7,12-dimethylbenz[a]anthracene (DMBA) on postnatal day 50. No differences in 
      maternal serum estradiol (P = 0.19) and IGF-1 levels (P = 0.15) at GD 19 or birth 
      weight among the milk and water groups were seen, but estradiol, and IGF-1 levels 
      and birth weight were numerically higher in the LIM group than in the HIM group. 
      Puberty onset occurred earlier in the LIM offspring than in controls (P = 0.03). 
      Although the high isoflavone content seemed to prevent the effect on circulating 
      estradiol and IGF-1 levels and advanced puberty onset seen in the LIM group, HIM 
      increased DMBA-DNA adducts in the mammary gland and tended to increase mammary 
      tumorigenesis. In contrast, offspring exposed to LIM in utero, did not exhibit 
      increased breast cancer risk, despite having higher estradiol and IGF-1 
      environment and consequently earlier puberty onset. These results indicate that 
      the phytochemical content in the cow's milk, consumed by a pregnant dam, 
      determines how milk affects the offspring.
FAU - Nielsen, Tina Skau
AU  - Nielsen TS
AD  - Department of Animal Health and Bioscience, Faculty of Agricultural Sciences, 
      Aarhus University, Tjele, Denmark. TinaS.Nielsen@agrsci.dk
FAU - Purup, Stig
AU  - Purup S
FAU - Warri, Anni
AU  - Warri A
FAU - Godschalk, Roger W
AU  - Godschalk RW
FAU - Hilakivi-Clarke, Leena
AU  - Hilakivi-Clarke L
LA  - eng
PT  - Journal Article
DEP - 20110405
PL  - United States
TA  - Cancer Prev Res (Phila)
JT  - Cancer prevention research (Philadelphia, Pa.)
JID - 101479409
RN  - 0 (Carcinogens)
RN  - 0 (Isoflavones)
RN  - 57-97-6 (9,10-Dimethyl-1,2-benzanthracene)
SB  - IM
MH  - 9,10-Dimethyl-1,2-benzanthracene/*toxicity
MH  - Animals
MH  - Carcinogens/*toxicity
MH  - Cattle
MH  - Disease Susceptibility
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Isoflavones/*therapeutic use
MH  - Mammary Neoplasms, Experimental/chemically induced/*prevention & control
MH  - *Maternal Exposure
MH  - *Milk
MH  - Pregnancy
MH  - Pregnancy Complications, Neoplastic/drug therapy
MH  - Prenatal Exposure Delayed Effects/*drug therapy
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2011/04/07 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/04/07 06:00
PHST- 2011/04/07 06:00 [entrez]
PHST- 2011/04/07 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 1940-6207.CAPR-10-0220 [pii]
AID - 10.1158/1940-6207.CAPR-10-0220 [doi]
PST - ppublish
SO  - Cancer Prev Res (Phila). 2011 May;4(5):694-701. doi: 
      10.1158/1940-6207.CAPR-10-0220. Epub 2011 Apr 5.