PMID- 21467254
OWN - NLM
STAT- MEDLINE
DCOM- 20110811
LR  - 20220309
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 259
IP  - 3
DP  - 2011 Jun
TI  - Acute, subacute, and chronic myocardial infarction: quantitative comparison of 2D 
      and 3D late gadolinium enhancement MR imaging.
PG  - 704-11
LID - 10.1148/radiol.11102216 [doi]
AB  - PURPOSE: To assess a late gadolinium enhancement (LGE) single-breath-hold 
      three-dimensional (3D) inversion recovery magnetic resonance (MR) imaging 
      sequence for the quantification of myocardial scar mass and transmurality in 
      comparison with a clinically established two-dimensional (2D) sequence. MATERIALS 
      AND METHODS: All patients gave written informed consent to participate in this 
      institutional review board-approved study. Ninety patients (84 men; mean age, 
      54.4 years +/- 10.8 [standard deviation]) with acute (n = 30), subacute (n = 30), 
      or chronic (n = 30) myocardial infarction were included. Imaging was performed by 
      using a 1.5-T clinical MR imaging system. Spatial resolution was identical for 3D 
      and 2D images (1.5 x 1.5 mm(2); section thickness, 8 mm; no section gap). 
      Quantitative comparisons of myocardial mass (in grams), scar mass (in grams), and 
      scar transmurality (on a five-point scale) were performed by using the Pearson 
      correlation and Bland-Altman analysis (for myocardial and scar mass) or kappa 
      statistics (for transmurality). RESULTS: There were no significant differences 
      between 2D and 3D data sets in terms of mean myocardial mass (2D: 148.3 g +/- 35.1; 
      3D: 148.1 g +/- 34.6; P = .76) and scar tissue mass (2D: 31.8 g +/- 14.6; 3D: 31.6 g 
      +/- 15.5; P = .39), with strong and significant correlation regarding both 
      myocardial mass (r = 0.982; P < .001) and scar tissue mass (r = 0.980; P < .001). 
      Bland-Altman analysis showed a mean difference of 0.21 g +/- 6.64 (range, -19.64 to 
      18.44 g) for myocardial mass and a mean difference of 0.26 g +/- 2.88 (range, -7.15 
      to 7.74 g) for scar mass between the 2D and 3D data sets. Agreement regarding 
      scar transmurality was good (kappa = 0.75). Acquisition time was significantly 
      shorter for 3D data sets (26.7 seconds +/- 4.4 vs 367.7 seconds +/- 56.4; P < .001). 
      CONCLUSION: Three-dimensional LGE MR imaging enables quantitative evaluation of 
      scar tissue mass and transmurality in patients with acute, subacute, or chronic 
      myocardial infarction at significantly reduced acquisition times compared with 2D 
      LGE MR imaging.
CI  - RSNA, 2011
FAU - Goetti, Robert
AU  - Goetti R
AD  - Department of Diagnostic Radiology, University Hospital Zurich, Raemistrasse 100, 
      CH-8091 Zurich, Switzerland.
FAU - Kozerke, Sebastian
AU  - Kozerke S
FAU - Donati, Olivio F
AU  - Donati OF
FAU - Surder, Daniel
AU  - Surder D
FAU - Stolzmann, Paul
AU  - Stolzmann P
FAU - Kaufmann, Philipp A
AU  - Kaufmann PA
FAU - Luscher, Thomas F
AU  - Luscher TF
FAU - Corti, Roberto
AU  - Corti R
FAU - Manka, Robert
AU  - Manka R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110405
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 1BJ477IO2L (gadobutrol)
SB  - IM
MH  - Acute Disease
MH  - Chi-Square Distribution
MH  - Chronic Disease
MH  - Contrast Media
MH  - Female
MH  - Humans
MH  - Image Enhancement/methods
MH  - Imaging, Three-Dimensional/*methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*diagnosis/pathology
MH  - Organometallic Compounds
MH  - Statistics, Nonparametric
EDAT- 2011/04/07 06:00
MHDA- 2011/08/13 06:00
CRDT- 2011/04/07 06:00
PHST- 2011/04/07 06:00 [entrez]
PHST- 2011/04/07 06:00 [pubmed]
PHST- 2011/08/13 06:00 [medline]
AID - radiol.11102216 [pii]
AID - 10.1148/radiol.11102216 [doi]
PST - ppublish
SO  - Radiology. 2011 Jun;259(3):704-11. doi: 10.1148/radiol.11102216. Epub 2011 Apr 5.