PMID- 21467762
OWN - NLM
STAT- MEDLINE
DCOM- 20120313
LR  - 20190606
IS  - 1347-7439 (Electronic)
IS  - 0916-7250 (Linking)
VI  - 73
IP  - 8
DP  - 2011 Aug
TI  - The diagnostic significance of the plasma N-terminal pro-B-type natriuretic 
      Peptide concentration in asymptomatic cats with cardiac enlargement.
PG  - 971-5
AB  - We evaluated the diagnostic significance of the N-terminal pro-B-type natriuretic 
      peptide (NT-proBNP) concentration in asymptomatic cats with cardiac enlargement. 
      The plasma NT-proBNP concentration was measured in 21 clinically healthy control 
      cats, and 67 asymptomatic cats with cardiac enlargement defined as end-diastolic 
      interventricular septum thickness (IVSd) and/or diastolic left ventricular 
      posterior wall thickness (LVPWd) >0.6 cm, vertebla heart scale (VHS) >7.8, and/or 
      left atria/aorta ratio (LA/Ao) >1.5. The plasma NT-proBNP concentration in the 
      asymptomatic cats with cardiac enlargement (median: 662.0, range: 24.0-2,449.0 
      pmol/l) was significantly higher than that in the controls (24.0, 24.0-95.0 
      pmol/l, P<0.001). The plasma NT-proBNP concentration was significantly correlated 
      with the VHS, LA/Ao, IVSd and LVPWd (r=0.578, P<0.001; r=0.462, P<0.001; r=0.563, 
      P<0.001; and r=0.764, P<0.001, respectively). Receiver operating characteristic 
      analysis showed a cut-off value of 95.0 pmol/l for the detection of asymptomatic 
      cats with cardiac enlargement, sensitivity and specificity of 88.1 and 100%, 
      respectively, and an area under the curve of 0.971. These results suggest that 
      the determination of the plasma NT-proBNP concentration can be a useful screening 
      test for asymptomatic cats with cardiac enlargement.
FAU - Tominaga, Yoshinori
AU  - Tominaga Y
AD  - Laboratory of Veterinary Integrative Medicine, School of Veterinary Medicine, 
      Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 
      Tokyo, Japan.
FAU - Miyagawa, Yuichi
AU  - Miyagawa Y
FAU - Toda, Noriko
AU  - Toda N
FAU - Takemura, Naoyuki
AU  - Takemura N
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
DEP - 20110404
PL  - Japan
TA  - J Vet Med Sci
JT  - The Journal of veterinary medical science
JID - 9105360
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Animals
MH  - Asymptomatic Diseases
MH  - Biomarkers/blood
MH  - Cardiomegaly/blood/diagnosis/diagnostic imaging/*veterinary
MH  - Cat Diseases/blood/*diagnosis/diagnostic imaging
MH  - Cats
MH  - Female
MH  - Male
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
MH  - ROC Curve
MH  - Sensitivity and Specificity
MH  - Ultrasonography
EDAT- 2011/04/07 06:00
MHDA- 2012/03/14 06:00
CRDT- 2011/04/07 06:00
PHST- 2011/04/07 06:00 [entrez]
PHST- 2011/04/07 06:00 [pubmed]
PHST- 2012/03/14 06:00 [medline]
AID - JST.JSTAGE/jvms/10-0303 [pii]
AID - 10.1292/jvms.10-0303 [doi]
PST - ppublish
SO  - J Vet Med Sci. 2011 Aug;73(8):971-5. doi: 10.1292/jvms.10-0303. Epub 2011 Apr 4.