PMID- 21470362
OWN - NLM
STAT- MEDLINE
DCOM- 20110725
LR  - 20151119
IS  - 1475-097X (Electronic)
IS  - 1475-0961 (Linking)
VI  - 31
IP  - 3
DP  - 2011 May
TI  - Non-invasive stroke volume measurement by cardiac magnetic resonance imaging and 
      inert gas rebreathing in pulmonary hypertension.
PG  - 221-6
LID - 10.1111/j.1475-097X.2010.01004.x [doi]
AB  - OBJECTIVE:   Right ventricular function determines the prognosis of pulmonary 
      hypertension (PAH). Measurement of stroke volume (SV) non-invasively could be a 
      promising method to monitor disease progression. Cardiac magnetic resonance (CMR) 
      imaging is recognized as an accurate and reproducible method to measure SV. Inert 
      gas rebreathing (IGR) using acetylene is a validated but cumbersome method for 
      pulmonary blood flow (PBF) measurement in PAH. A more convenient rebreathing 
      technique using rapid photoacoustic analysis of nitrous oxide has been introduced 
      and validated in left heart failure. We investigated the accuracy of CMR imaging 
      and IGR using photoacoustic analysis to measure SV in patients under 
      investigation for PAH. METHODS:   Thirty-three patients (16female symbol:17male symbol) with suspected 
      PAH following echocardiography had SV measured by CMR imaging (using pulmonary 
      arterialCMR PA and aortic CMR Ao flow methods) and IGR. The results were 
      compared with our reference standard: thermodilution (TD) measured during right 
      heart catheterization (RHC). RESULTS:   All methods showed similar correlation 
      for SV. Bland-Altman analysis confirmed acceptable levels of agreement between 
      the four techniques. TD versus CMR Ao flow had bias (limits of agreement) of 
      -5.41 ml (-22.37 to 11.56 ml), TD versus CMR PA flow 0.12 ml (-20.13 to 20.37 ml) 
      and TD versus IGR 6.25 ml (-16.01 to 28.51 ml). CONCLUSION:   Cardiac magnetic 
      resonance imaging and IGR using photoacoustic analysis in patients with suspected 
      PAH provided non-invasive measurements of SV that agreed closely with those 
      obtained from TD measured during RHC.
CI  - (c) 2011 The Authors. Clinical Physiology and Functional Imaging (c) 2011 
      Scandinavian Society of Clinical Physiology and Nuclear Medicine.
FAU - McLure, Lindsey E R
AU  - McLure LE
AD  - Scottish Pulmonary Vascular Unit, Golden Jubilee National Hospital, Clydebank, 
      West Dunbartonshire, Scotland, UK.
FAU - Brown, Aileen
AU  - Brown A
FAU - Lee, Waiting N
AU  - Lee WN
FAU - Church, Alistair C
AU  - Church AC
FAU - Peacock, Andrew J
AU  - Peacock AJ
FAU - Johnson, Martin K
AU  - Johnson MK
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110107
PL  - England
TA  - Clin Physiol Funct Imaging
JT  - Clinical physiology and functional imaging
JID - 101137604
RN  - K50XQU1029 (Nitrous Oxide)
SB  - IM
MH  - Administration, Inhalation
MH  - Adult
MH  - Aged
MH  - Blood Pressure
MH  - *Breath Tests
MH  - Cardiac Catheterization
MH  - Female
MH  - Humans
MH  - Hypertension, Pulmonary/*diagnosis/physiopathology
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - *Nitrous Oxide/administration & dosage
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Scotland
MH  - *Stroke Volume
MH  - Thermodilution
MH  - *Ventricular Function, Right
EDAT- 2011/04/08 06:00
MHDA- 2011/07/26 06:00
CRDT- 2011/04/08 06:00
PHST- 2011/04/08 06:00 [entrez]
PHST- 2011/04/08 06:00 [pubmed]
PHST- 2011/07/26 06:00 [medline]
AID - 10.1111/j.1475-097X.2010.01004.x [doi]
PST - ppublish
SO  - Clin Physiol Funct Imaging. 2011 May;31(3):221-6. doi: 
      10.1111/j.1475-097X.2010.01004.x. Epub 2011 Jan 7.