PMID- 21471146
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20220321
IS  - 1879-0844 (Electronic)
IS  - 1388-9842 (Linking)
VI  - 13
IP  - 5
DP  - 2011 May
TI  - MitraClip(R) therapy in patients with end-stage systolic heart failure.
PG  - 569-76
LID - 10.1093/eurjhf/hfr029 [doi]
AB  - AIMS: To assess the feasibility, short-term durability and clinical outcomes of 
      MitraClip(R) therapy for mitral regurgitation (MR) in patients with end-stage heart 
      failure and a severely reduced left ventricular (LV) ejection fraction. METHODS 
      AND RESULTS: We analysed retrospectively collected data from seven European 
      centres. Included in the study were 50 heart failure patients [mean age 70 +/- 11 
      years, 38 men (76%)] with a LV ejection fraction </=25% and MR of at least grade 
      3+. All patients had functional MR, were in New York Heart Association (NYHA) 
      functional class III or IV, and their mean logistic EuroSCORE was 34%. The 
      patients underwent a total of 53 MitraClip(R) procedures; one or more clips were 
      implanted in 50 procedures (48 patients), for an acute procedural success rate of 
      94%. Severity of MR was reduced in all successfully treated patients, 44 (92%) 
      were discharged with MR </=2+. Thirty-day mortality was 6%; cumulative survival at 
      6 months was 81.2%. Clinical and echocardiographic 6-month follow-up data were 
      obtained from 32 and 31 successfully treated patients, respectively. At 6 months, 
      MR </=2+ was present in 27 (87%) of 31 patients, and 23 (72%) of 32 patients were 
      in NYHA functional class I or II. Six-minute walk distance improved 
      significantly, and significant reductions in LV volumes indicative of reverse LV 
      remodelling were concordant with significant reductions in N-terminal pro-brain 
      natriuretic peptide plasma levels. CONCLUSION: MitraClip(R) therapy reduces 
      functional MR in patients with end-stage heart failure and marked LV dysfunction 
      and entails clinical benefit at 6 months.
FAU - Franzen, Olaf
AU  - Franzen O
AD  - Department of General and Interventional Cardiology, University Heart Centre, 
      Hamburg, Germany. owfranzen@gmx.de
FAU - van der Heyden, Jan
AU  - van der Heyden J
FAU - Baldus, Stephan
AU  - Baldus S
FAU - Schluter, Michael
AU  - Schluter M
FAU - Schillinger, Wolfgang
AU  - Schillinger W
FAU - Butter, Christian
AU  - Butter C
FAU - Hoffmann, Rainer
AU  - Hoffmann R
FAU - Corti, Roberto
AU  - Corti R
FAU - Pedrazzini, Giovanni
AU  - Pedrazzini G
FAU - Swaans, Martin J
AU  - Swaans MJ
FAU - Neuss, Michael
AU  - Neuss M
FAU - Rudolph, Volker
AU  - Rudolph V
FAU - Surder, Daniel
AU  - Surder D
FAU - Grunenfelder, Jurg
AU  - Grunenfelder J
FAU - Eulenburg, Christine
AU  - Eulenburg C
FAU - Reichenspurner, Hermann
AU  - Reichenspurner H
FAU - Meinertz, Thomas
AU  - Meinertz T
FAU - Auricchio, Angelo
AU  - Auricchio A
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20110406
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
CIN - Eur J Heart Fail. 2011 May;13(5):472-4. PMID: 21505057
MH  - Aged
MH  - Comorbidity
MH  - Feasibility Studies
MH  - Female
MH  - Heart Failure/*epidemiology/mortality
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve Insufficiency/diagnostic 
      imaging/epidemiology/mortality/physiopathology/*therapy
MH  - Natriuretic Peptide, Brain/blood
MH  - Peptide Fragments/blood
MH  - *Prostheses and Implants
MH  - Stroke Volume
MH  - Treatment Outcome
MH  - Ultrasonography
MH  - Ventricular Dysfunction, Left/epidemiology
EDAT- 2011/04/08 06:00
MHDA- 2011/08/24 06:00
CRDT- 2011/04/08 06:00
PHST- 2011/04/08 06:00 [entrez]
PHST- 2011/04/08 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
AID - hfr029 [pii]
AID - 10.1093/eurjhf/hfr029 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2011 May;13(5):569-76. doi: 10.1093/eurjhf/hfr029. Epub 2011 
      Apr 6.