PMID- 21471246
OWN - NLM
STAT- MEDLINE
DCOM- 20110804
LR  - 20211020
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Print)
IS  - 0022-538X (Linking)
VI  - 85
IP  - 12
DP  - 2011 Jun
TI  - Common HIV-1 peptide variants mediate differential binding of KIR3DL1 to HLA-Bw4 
      molecules.
PG  - 5970-4
LID - 10.1128/JVI.00412-11 [doi]
AB  - Epidemiological studies have shown the protective effect of KIR3DL1/HLA-Bw4 
      genotypes in human immunodeficiency virus type 1 (HIV-1) infection; however, the 
      functional correlates for the protective effect remain unknown. We investigated 
      whether human leukocyte antigen (HLA)-Bw4-presented HIV-1 peptides could affect 
      the interaction between the inhibitory natural killer (NK) cell receptor KIR3DL1 
      and its ligand HLA-Bw4. Distinct HIV-1 epitopes differentially modulated the 
      binding of KIR3DL1 to HLA-Bw4. Furthermore, cytotoxic T lymphocyte (CTL) escape 
      mutations within the immunodominant HLA-B57 (Bw4)-restricted Gag epitope 
      TSTLQEQIGW abrogated KIR3DL1 binding to HLA-B57, suggesting that sensing of CTL 
      escape variants by NK cells can contribute to the protective effect of the 
      KIR3DL1/HLA-Bw4 compound genotype.
FAU - Fadda, Lena
AU  - Fadda L
AD  - Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital, Bldg. 
      149, 13th Street, Charlestown, MA 02129, USA.
FAU - O'Connor, Geraldine M
AU  - O'Connor GM
FAU - Kumar, Swati
AU  - Kumar S
FAU - Piechocka-Trocha, Alicja
AU  - Piechocka-Trocha A
FAU - Gardiner, Clair M
AU  - Gardiner CM
FAU - Carrington, Mary
AU  - Carrington M
FAU - McVicar, Daniel W
AU  - McVicar DW
FAU - Altfeld, Marcus
AU  - Altfeld M
LA  - eng
GR  - R01 AI067031/AI/NIAID NIH HHS/United States
GR  - R01AI067031/AI/NIAID NIH HHS/United States
GR  - ImNIH/Intramural NIH HHS/United States
GR  - HHSN261200800001C/RC/CCR NIH HHS/United States
GR  - P30 AI060354/AI/NIAID NIH HHS/United States
GR  - HHSN261200800001E/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110406
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Epitopes, T-Lymphocyte)
RN  - 0 (Gene Products, gag)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-Bw4 antigen)
RN  - 0 (Immunodominant Epitopes)
RN  - 0 (KIR3DL1 protein, human)
RN  - 0 (Peptides)
RN  - 0 (Receptors, KIR3DL1)
SB  - IM
MH  - Amino Acid Sequence
MH  - Epitopes, T-Lymphocyte/chemistry/genetics/*immunology
MH  - Gene Products, gag/chemistry/*genetics/immunology/metabolism
MH  - *Genetic Variation
MH  - HIV Infections/immunology/virology
MH  - HIV-1/genetics/*immunology
MH  - HLA-B Antigens/genetics/*metabolism
MH  - Humans
MH  - Immune Evasion
MH  - Immunodominant Epitopes
MH  - Jurkat Cells
MH  - Killer Cells, Natural/immunology/metabolism
MH  - Peptides/chemistry/*genetics/immunology/metabolism
MH  - Point Mutation
MH  - Protein Binding/drug effects
MH  - Receptors, KIR3DL1/*metabolism
MH  - T-Lymphocytes, Cytotoxic/immunology/metabolism
PMC - PMC3126328
EDAT- 2011/04/08 06:00
MHDA- 2011/08/05 06:00
PMCR- 2011/12/01
CRDT- 2011/04/08 06:00
PHST- 2011/04/08 06:00 [entrez]
PHST- 2011/04/08 06:00 [pubmed]
PHST- 2011/08/05 06:00 [medline]
PHST- 2011/12/01 00:00 [pmc-release]
AID - JVI.00412-11 [pii]
AID - 0412-11 [pii]
AID - 10.1128/JVI.00412-11 [doi]
PST - ppublish
SO  - J Virol. 2011 Jun;85(12):5970-4. doi: 10.1128/JVI.00412-11. Epub 2011 Apr 6.